Immunopathogenesis of systemic sclerosis

被引：128

作者：

White, B ^{[1
]}

机构：

[1] VET ADM MED CTR, BALTIMORE, MD 21218 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 1996年 / 22卷 / 04期

关键词：

D O I：

10.1016/S0889-857X(05)70296-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Activated T cells, B cells, and nonspecific inflammatory cells cause tissue damage in patients with systemic sclerosis (SSc). Of these activated cells, the T cells play a central role. Soluble mediators and cellular cytotoxicity are major mechanisms of activating or damaging fibroblasts, endothelial cells, and other vascular cells in SSc. Certain autoantibody targets are specific for SSc, and some targets are homologous to viruses. At this time, however, the contributions of antibodies to tissue damage in SSc patients are less apparent than the contributions of cellular immunity.

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页码：695 / +

页数：1

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