Mitochondrial signaling in apoptosis: Mitochondrial daggers to the breaking heart

被引：38

作者：

Gottlieb, RA ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, Div Hematol, La Jolla, CA 92037 USA

来源：

BASIC RESEARCH IN CARDIOLOGY | 2003年 / 98卷 / 04期

关键词：

D O I：

10.1007/s00395-003-0404-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitochondria respond to signals from the cytoplasmic environment, including energy needs, substrate and oxygen availability, ion fluxes, as well as kinase and proteolytic signals. They integrate these complex, often conflicting signals with a coordinated response, whether for growth, hibernation, or apoptosis. In this review we consider the panoply of signals that impact the mitochondria, and focus particularly on the apoptotic pathways in which the mitochondria stand at the crossroads.

引用

页码：242 / 249

页数：8

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