Cytotoxic T lymphocytes in HIV-1 infection: a killing paradox?

被引：28

作者：

Klein, MR ^{[1
]}

van der Burg, SH

Pontesilli, O

Miedema, F

机构：

[1] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Dept Clin Viroimmunol, Amsterdam, Netherlands

[2] Univ Amsterdam, Expt & Clin Immunol Lab, NL-1012 WX Amsterdam, Netherlands

[3] Univ Leiden Hosp, Dept Immunohaematol & Blood Bank, NL-2300 RC Leiden, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Human Retrovirol, NL-1105 AZ Amsterdam, Netherlands

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 07期

关键词：

D O I：

10.1016/S0167-5699(98)01288-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A decade after the first publications on HIV-1-specific cytotoxic T lymphocytes (CTLs) their role in the pathogenesis of AIDS is still equivocal. There is an ongoing debate as a whether HIV-1-specific CTLs control the viremia or mediate CD4(+) T-cell depletion and progression to AIDS. However, experimental data in favour of a beneficial role of HIV-1-specific CTLs are mounting. Here, Michel Klein and colleagues try to depict and reconcile the current paradoxes of HIV-1-specific CTL responses.

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页码：317 / 324

页数：8

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