Dynamic simulation of the human red blood cell metabolic network

被引：65

作者：

Jamshidi, N ^{[1
]}

Edwards, JS

Fahland, T

Church, GM

Palsson, BO

机构：

[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[3] Univ Delaware, Dept Chem Engn, Newark, DE 19711 USA

来源：

BIOINFORMATICS | 2001年 / 17卷 / 03期

关键词：

D O I：

10.1093/bioinformatics/17.3.286

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have developed a Mathematica (R) application package to perform dynamic simulations of the red blood cell (RBC) metabolic network. The package relies on, and integrates, many years of mathematical modeling and biochemical work on red blood cell metabolism. The extensive data regarding the red blood cell metabolic network and the previous kinetic analysis of all the individual components makes the human RBC an ideal 'model' system for mathematical metabolic models. The Mathematica package can be used to understand the dynamics and regulatory characteristics of the red blood cell.

引用

页码：286 / 287

页数：2

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