FOXO animal models reveal a variety of diverse roles for FOXO transcription factors
被引:125
作者:
Arden, K. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Ludwig Inst Canc Res, Dept Med, Sch Med, La Jolla, CA 92093 USAUniv Calif San Diego, Ludwig Inst Canc Res, Dept Med, Sch Med, La Jolla, CA 92093 USA
Arden, K. C.
[1
]
机构:
[1] Univ Calif San Diego, Ludwig Inst Canc Res, Dept Med, Sch Med, La Jolla, CA 92093 USA
The Foxo subfamily of FOX transcription factors plays a variety of roles in a broad assortment of diverse physiological processes including cellular differentiation, tumor suppression, metabolism, cell cycle arrest, cell death and protection from stress. Animal models have proved to be invaluable tools in furthering our understanding of the role of particular genes in complex organismal processes. Multiple animal models in diverse species, including Caenorhabditis elegans, Drosophila. melanogaster and the laboratory mouse, exist for the Foxo family of transcription factors. Foxo genes are highly conserved throughout the evolution and each of these model systems has provided valuable insight into the roles of Foxo factors. Many roles are conserved among the different model organisms. Several Foxo-related animal model systems are reviewed here along with the knowledge gleaned to date from each model system.
机构:
Columbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
Adachi, Masayuki
;
论文数: 引用数:
h-index:
机构:
Osawa, Yosuke
;
Uchinami, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
Uchinami, Hiroshi
;
Kitamura, Tadahiro
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
Kitamura, Tadahiro
;
Accili, Domenico
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
Accili, Domenico
;
Brenner, David A.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
机构:Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
Castrillon, DH
;
Miao, LL
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
Miao, LL
;
Kollipara, R
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
Kollipara, R
;
Horner, JW
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
Horner, JW
;
DePinho, RA
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
Jacobs, FMJ
;
van der Heide, LP
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
van der Heide, LP
;
Wijchers, PJEC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
Wijchers, PJEC
;
Burbach, JPH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
Burbach, JPH
;
Hoekman, MFM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
Hoekman, MFM
;
Smidt, MP
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
机构:
Columbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
Adachi, Masayuki
;
论文数: 引用数:
h-index:
机构:
Osawa, Yosuke
;
Uchinami, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
Uchinami, Hiroshi
;
Kitamura, Tadahiro
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
Kitamura, Tadahiro
;
Accili, Domenico
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
Accili, Domenico
;
Brenner, David A.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
机构:Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
Castrillon, DH
;
Miao, LL
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
Miao, LL
;
Kollipara, R
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
Kollipara, R
;
Horner, JW
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
Horner, JW
;
DePinho, RA
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USAHarvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
Jacobs, FMJ
;
van der Heide, LP
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
van der Heide, LP
;
Wijchers, PJEC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
Wijchers, PJEC
;
Burbach, JPH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
Burbach, JPH
;
Hoekman, MFM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands
Hoekman, MFM
;
Smidt, MP
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, NetherlandsUniv Med Ctr, Rudolf Magnus Inst Neurosci, Dept Pharmacol & Anat, NL-3584 CG Utrecht, Netherlands