FOXO animal models reveal a variety of diverse roles for FOXO transcription factors

被引:125
作者
Arden, K. C. [1 ]
机构
[1] Univ Calif San Diego, Ludwig Inst Canc Res, Dept Med, Sch Med, La Jolla, CA 92093 USA
关键词
FOXO; FKHR; daf-16; dFoxo; animal models;
D O I
10.1038/onc.2008.27
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Foxo subfamily of FOX transcription factors plays a variety of roles in a broad assortment of diverse physiological processes including cellular differentiation, tumor suppression, metabolism, cell cycle arrest, cell death and protection from stress. Animal models have proved to be invaluable tools in furthering our understanding of the role of particular genes in complex organismal processes. Multiple animal models in diverse species, including Caenorhabditis elegans, Drosophila. melanogaster and the laboratory mouse, exist for the Foxo family of transcription factors. Foxo genes are highly conserved throughout the evolution and each of these model systems has provided valuable insight into the roles of Foxo factors. Many roles are conserved among the different model organisms. Several Foxo-related animal model systems are reviewed here along with the knowledge gleaned to date from each model system.
引用
收藏
页码:2345 / 2350
页数:6
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