The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice

被引：84

作者：

Arakawa, Mie ^{[1
]}

Masaki, Takayuki ^{[1
]}

Nishimura, Junko ^{[1
]}

Seike, Masataka ^{[1
]}

Yoshimatsu, Hironobu ^{[1
]}

机构：

[1] Oita Univ, Fac Med, Dept Internal Med 1, Oita 8795593, Japan

来源：

ENDOCRINE JOURNAL | 2011年 / 58卷 / 03期

关键词：

BCAA; Tissue triglyceride; Obesity; Adiposity; PROLIFERATOR-ACTIVATED RECEPTORS; ALPHA-NULL MICE; PEROXISOME-PROLIFERATOR; ADIPOSE-TISSUE; PPAR-ALPHA; INSULIN SENSITIVITY; SKELETAL-MUSCLE; LEUCINE SUPPLEMENTATION; METABOLIC SYNDROME; LIVER-CIRRHOSIS;

D O I：

10.1507/endocrj.K10E-221

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has been demonstrated the involvement of branched-chain amino acids (BCAA) on obesity and related metabolic disorder. We investigated the effects of branched-chain amino acids (BCAA) on obesity and on glucose/fat homeostasis in mice fed on a high-fat (45%) diet. BCAA was dissolved in 0.5% methylcellulose and added to the drinking water (BCAA.-treated group). A high-fat diet was provided for 6 weeks and BCAA was given for 2 weeks. The BCAA-treated group gained almost 7% less body weight and had less epididymal adipose tissue (WAT) mass than the control group (p < 0.05). BCAA supplementation also reduced the hepatic and skeletal muscle triglyceride (TG) concentrations (p < 0.05). The hepatic levels of PPAR-alpha and uncoupling protein (UCP) 2, and the level of PPAR-alpha and UCP3 in the skeletal muscle were greater in die BCAA-treated group than in the control mice (p < 0.05). These results demonstrate that the liver and muscle TO concentration are less in BCAA-treated group. BCAA affects PPAR-alpha and UCP expression in muscle and liver tissue.

引用

页码：161 / 170

页数：10

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