Applying genomic technologies in environmental health research: Challenges and opportunities

被引：21

作者：

Christiani, DC

Sharp, RR

Collman, GW

Suk, WA

机构：

[1] Harvard Univ, Sch Publ Hlth, Occupat Hlth Program, Dept Environm Hlth, Boston, MA 02115 USA

[2] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

[4] NIEHS, Off Sci Director, NIH, Res Triangle Pk, NC 27709 USA

[5] NIEHS, Div Extramural Res, NIH, Res Triangle Pk, NC 27709 USA

[6] Duke Univ, Ctr Study Med Eth & Humanities, Durham, NC 27706 USA

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2001年 / 43卷 / 06期

关键词：

D O I：

10.1097/00043764-200106000-00003

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Recent discoveries in molecular biology and genetics have made it possible for environmental health researchers to examine how genetic characteristics affect response to environmental exposures. Understanding such gene-environment interactions offers exciting possibilities for the prevention and control of environmentally induced diseases. Despite these potential benefits, the collection and analysis of genetic information in environmental health research presents many of the same ethical, legal, and social (ELSI) challenges found in other types of genetic research. In this article, we describe a number of ELSI challenges in environmental genomic research and the opportunities and responsibilities that accompany this research.

引用

页码：526 / 533

页数：8

共 46 条

[1] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].

AMES, BN ;

SHIGENAGA, MK ;

HAGEN, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922

[2]

AMOS CI, 1992, CANCER EPIDEM BIOMAR, V1, P505

[3] PRIVACY RULES FOR DNA DATA-BANKS - PROTECTING CODED FUTURE DIARIES [J].

ANNAS, GJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (19) :2346-2350

[4]

[Anonymous], 1997, ENVIRON HEALTH PERSP, V105, P578

[5]

[Anonymous], 1993, MOL EPIDEMIOLOGY PRI

[6]

BAIRD PA, 1995, PERSPECT BIOL MED, V38, P159

[7]

Bartsch H, 2000, CANCER EPIDEM BIOMAR, V9, P3

[8]

Bentley DR, 2000, MED RES REV, V20, P189, DOI 10.1002/(SICI)1098-1128(200005)20:3<189::AID-MED2>3.0.CO

[9]

2-#

[10] CANCER GENES - SINGLE AND SUSCEPTIBILITY - EXPOSING THE DIFFERENCE [J].

CAPORASO, N ;

GOLDSTEIN, A .

PHARMACOGENETICS, 1995, 5 (02) :59-63

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