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In vitro activities of DU-1102, a new trioxaquine derivative, against Plasmodium falciparum isolates

被引：57
作者：
Basco, LK
Dechy-Cabaret, O
Ndounga, M
Meche, FS
Robert, A
Meunier, B
机构：
[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France
[2] OCEAC, Inst Rech Dev, Lab Rech Paludisme, Yaounde, Cameroon
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 06期
关键词：
D O I：
10.1128/AAC.45.6.1886-1888.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum. There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.
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页码：1886 / 1888
页数：3
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