Risk factors and confounders in the geographical clustering of schizophrenia

被引:17
作者
Torrey, EF
Mortensen, PB
Pedersen, CB
Wohlfahrt, J
Melbye, M
机构
[1] Stanley Fdn, Res Programs, Bethesda, MD USA
[2] Inst Basic Psychiat Res, Dept Psychiat Demog, Aarhus, Denmark
[3] Danish Epidemiol Sci Ctr, Copenhagen, Denmark
关键词
epidemiology; geographical clusters; schizophrenia; urbanicity;
D O I
10.1016/S0920-9964(00)00081-5
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
In response to previous reports of geographical clustering of individuals with psychosis, a study was carried out in Denmark utilizing the national case register. Two-thousand one-hundred and ninety-nine (2199) individuals with schizophrenia were divided by place of birth into 217 geographical areas and analyzed by age, gender, month of birth, genetic relatedness, and degree of urbanization of birthplace. Heterogeneity was ascertained using log-linear Poisson regression. The greatest amount of heterogeneity was associated with degree of urbanization of place of birth. Heterogeneity was also associated with age-gender interaction and calendar period. When adjusted for these factors, there was no remaining heterogeneity, suggesting that all geographical clustering in our study was explained by the above factors. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:295 / 299
页数:5
相关论文
共 25 条
[1]  
[Anonymous], 1987, Statistical methods in cancer research, Vol 1-The analysis of case-control studies
[2]  
Armitage P, 1987, Statistical methods in medical research, V2nd
[3]  
BOOK JA, 1978, CLIN GENET, V14, P373
[4]  
Clayton D., 1993, STAT MODELS EPIDEMIO
[5]  
Faris REL, 1939, MENTAL DISORDERS URB
[6]   SCHIZOPHRENIA AND CITY RESIDENCE [J].
FREEMAN, H .
BRITISH JOURNAL OF PSYCHIATRY, 1994, 164 :39-50
[7]  
HURD H, 1973, REPORT COMMITTEE CON, V2, P93
[8]  
KAZANETZ EF, 1979, RIV PSICOLOGIA ANAL, V10, P193
[9]  
Kendler KS, 1996, ARCH GEN PSYCHIAT, V53, P1022
[10]  
KULCAR Z, 1971, AM J EPIDEMIOL, V94, P118