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New insights into the pathogenesis of systemic lupus erythematosus (SLE): the role of apoptosis

被引：38
作者：
Bijl, M
Limburg, PC
Kallenberg, CGM
机构：
[1] Univ Groningen Hosp, Dept Internal Med, Div Clin Immunol, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen Hosp, Dept Pathol & Lab Med, NL-9700 RB Groningen, Netherlands
来源：
NETHERLANDS JOURNAL OF MEDICINE | 2001年 / 59卷 / 02期
关键词：
pathogenesis; systemic lupus erythematosus; apoptosis;
D O I：
10.1016/S0300-2977(01)00131-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent years disturbances in the process of apoptosis and the clearance of apoptotic cells have been put forward as fundamental in the development of autoimmunity. In this review we will discuss the data which supply evidence for this theory. We will focus on SLE as the prototype of autoimmune disease and will review both animal studies and clinical studies in SLE patients. (C) 2001 Published by Elsevier Science B.V.
引用
收藏
页码：66 / 75
页数：10
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