Fibronectin is a hypoxia-independent target of the tumor suppressor VHL

被引：45

作者：

Bluyssen, HAR

Lolkema, MPJK

van Beest, M

Boone, M

Snijckers, CMJT

Los, M

Gebbink, MFBG

Braam, B

Holstege, FCP

Giles, RH

Voest, EE

机构：

[1] Univ Utrecht, Ctr Med, Dept Med Oncol, NL-3500 GA Utrecht, Netherlands

[2] Univ Utrecht, Ctr Med, Dept Nephrol & Hypertens, Utrecht, Netherlands

[3] Univ Utrecht, Ctr Med, Genom Lab, Utrecht, Netherlands

来源：

FEBS LETTERS | 2004年 / 556卷 / 1-3期

关键词：

VHL; fibronectin; microarray; renal cell carcinoma; hypoxia;

D O I：

10.1016/S0014-5793(03)01392-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The von Hippel-Lindau (VHL) tumor suppressor gene regulates the extracellular matrix by controlling fibronectin deposition. To identify novel VHL target genes, we subjected mRNA from VHL-deficient RCC cells (786-0-pRC) and a transfectant re-expressing wildtype VHL (786-0-VHL) to differential expression profiling. Among the differentially expressed genes, we detected that fibronectin is upregulated in the presence of VHL, while it is not affected by hypoxia. Thus regulation of fibronectin deposition by VHL occurs at the transcriptional level, irrespective of oxygen levels. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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收藏

页码：137 / 142

页数：6

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