Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

被引:385
作者
Elson, CO
Cong, Y
McCracken, VJ
Dimmitt, RA
Lorenz, RG
Weaver, CT
机构
[1] Univ Alabama Birmingham, Dept Med, Div Gastroenterol & Hepatol, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA
[3] Univ Alabama Birmingham, Dept Pediat, Div Neonatol, Birmingham, AL 35294 USA
关键词
D O I
10.1111/j.0105-2896.2005.00291.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
There are now many experimental models of inflammatory bowel disease (IBD), most of which are due to induced mutations in mice that result in an impaired homeostasis with the intestinal microbiota. These models can be clustered into several broad categories that, in turn, define the crucial cellular and molecular mechanisms of host microbial interactions in the intestine. The first of these components is innate immunity defined broadly to include both myeloid and epithelial cell mechanisms. A second component is the effector response of the adaptive immune system, which, in most instances, comprises the CD4(+) T cell and its relevant cytokines. The third component is regulation, which can involve multiple cell types, but again particularly involves CD4(+) T cells. Severe impairment of a single component can result in disease, but many models demonstrate milder defects in more than one component. The same is true for both spontaneous models of IBD, C3H/HeJBir and SAMPI/Yit mice. The thesis is advanced that 'multiple hits' or defects in these interacting components is required for IBD to occur in both mouse and human.
引用
收藏
页码:260 / 276
页数:17
相关论文
共 148 条
  • [1] Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
    Abreu, MT
    Taylor, KD
    Lin, YC
    Hang, T
    Gaiennie, J
    Landers, CJ
    Vasiliauskas, EA
    Kam, LY
    Rojany, M
    Papadakis, KA
    Rotter, JI
    Targan, SR
    Yang, HY
    [J]. GASTROENTEROLOGY, 2002, 123 (03) : 679 - 688
  • [2] TLR signaling in the gut in health and disease
    Abreu, MT
    Fukata, M
    Arditi, M
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 174 (08) : 4453 - 4460
  • [3] Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment
    Annacker, O
    Burlen-Defranoux, O
    Pimenta-Araujo, R
    Cumano, A
    Bandeira, A
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (07) : 3573 - 3580
  • [4] MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis
    Araki, A
    Kanai, T
    Ishikura, T
    Makita, S
    Uraushihara, K
    Iiyama, R
    Totsuka, T
    Takeda, K
    Akira, S
    Watanabe, M
    [J]. JOURNAL OF GASTROENTEROLOGY, 2005, 40 (01) : 16 - 23
  • [5] Aranda R, 1997, J IMMUNOL, V158, P3464
  • [6] Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    Ashcroft, GS
    Yang, X
    Glick, AB
    Weinstein, M
    Letterio, JJ
    Mizel, DE
    Anzano, M
    Greenwell-Wild, T
    Wahl, SM
    Deng, CX
    Roberts, AB
    [J]. NATURE CELL BIOLOGY, 1999, 1 (05) : 260 - 266
  • [7] An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    Asseman, C
    Mauze, S
    Leach, MW
    Coffman, RL
    Powrie, F
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (07) : 995 - 1003
  • [8] Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation
    Bamias, G
    Martin, C
    Mishina, M
    Ross, WG
    Rivera-Nieves, J
    Marini, M
    Cominelli, F
    [J]. GASTROENTEROLOGY, 2005, 128 (03) : 654 - 666
  • [9] Bioavailability of tobramycin after oral delivery in FVB mice using CRL-1605 copolymer, an inhibitor of P-glycoprotein
    Banerjee, SK
    Jagannath, C
    Hunter, RL
    Dasgupta, A
    [J]. LIFE SCIENCES, 2000, 67 (16) : 2011 - 2016
  • [10] Macroscopic, microscopic and biochemical characterisation of spontaneous colitis in a transgenic mouse, deficient in the multiple drug resistance 1a gene
    Banner, KH
    Cattaneo, C
    Le Net, JL
    Popovic, A
    Collins, D
    Gale, JD
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2004, 143 (05) : 590 - 598