SNARE complexes and neuroexocytosis: how many, how close?

被引：131

作者：

Montecucco, C

Schiavo, G

Pantano, S

机构：

[1] Univ Padua, Dipartimento Sci Biomed, I-35121 Padua, Italy

[2] Univ Padua, CNR, Ist Neurosci, I-35121 Padua, Italy

[3] Canc Res UK, Lond Res Inst, Lincolns Inn Fields Labs, Mol Neuropathobiol Lab, London WC2A 3PX, England

[4] Ist Veneto Med Mol, I-35129 Padua, Italy

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 07期

关键词：

D O I：

10.1016/j.tibs.2005.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulated secretion is an essential process in all eukaryotic cells. The release of molecules contained inside exocytic granules and synaptic vesicles is mediated by the assembly of a SNARE complex formed by the coil-coiling of three proteins: SNAP-25, syntaxin and VAMP/synaptobrevin. It seems that SNARE complexes assemble together in rosette-shaped super-complexes but there is controversy on the actual number (N) of copies of SNARE complexes that are necessary to mediate exocytosis. We discuss attempts to determine the value of N and suggest that N varies with the type of exocytic vesicles. In addition, we propose that the N value in neuroexocytosis can be estimated by the comparative use of different types of botulinum neurotoxins.

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收藏

页码：367 / 372

页数：6

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