Effects of prednisolone on specifically expressed genes in pediatric acute B-lymphoblastic leukemia

被引：7

作者：

Akiyama, Masaharu ^{[1
]}

Yamada, Osamu ^{[3
]}

Agawa, Miyuki ^{[2
]}

Yuza, Yuki ^{[1
]}

Yanagisawa, Takaaki ^{[1
]}

Eto, Yoshikatsu ^{[1
]}

Yamada, Hisashi ^{[2
]}

机构：

[1] Jikei Univ, Sch Med, Dept Pediat, Minato Ku, Tokyo 1058461, Japan

[2] Jikei Univ, Sch Med, Inst DNA Med, Div Mol Genet, Tokyo 1058461, Japan

[3] Tokyo Womens Med Univ, Dept Hematol, Tokyo, Japan

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2008年 / 30卷 / 04期

关键词：

acute lymphoblastic leukemia; prednisolone; cDNA; microarray; pre-B receptor;

D O I：

10.1097/MPH.0b013e318161a28f

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although glucocorticoid is essential in the treatment of pediatric acute lymphoblastic leukemia (ALL), their precise mechanisms of action remain unclear. We used DNA micro-array to evaluate prednisolone-regulated genes in pre-B ALL cells from 2 pediatric patients. We found up-regulation of 26 genes in ALL cells from both patients, compared with peripheral normal B lymphocytes before maintenance chemotherapy. Treatment with prednisolone for 48 hours induced down-regulation of 5 genes (terminal deoxynucleotidyl tranferase, heparin-binding epidermal growth factorlike growth factor, pre-B-lymphocyte genes 1 and 3, and immunoglobulin lambda-like polypeptide) among 26 specifically expressed genes in pre-B-ALL cells from both patients.

引用

页码：313 / 316

页数：4

共 21 条

[1] Childhood acute lymphoblastic leukemia: Prognostic value of initial peripheral blast count in good responders to prednisone [J].

Felice, MS ;

Zubizarreta, PA ;

Alfaro, EM ;

Sackmann-Muriel, F .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2001, 23 (07) :411-415

[2] Tyrosine kinase activation in the decision between growth, differentiation, and death responses initiated from the B cell antigen receptor [J].

Hsueh, RC ;

Scheuermann, RH .

ADVANCES IN IMMUNOLOGY, VOL 75, 2000, 75 :283-316

[3] Regulation of DNA metabolic enzymes upon induction of preB cell development and V(D)J recombination: Up-regulation of DNA polymerase delta [J].

Jessberger, R ;

Schar, P ;

Robins, P ;

Ferrari, E ;

Riwar, B ;

Hubscher, U .

NUCLEIC ACIDS RESEARCH, 1997, 25 (02) :289-296

[4]

Jumaa H, 2001, EUR J IMMUNOL, V31, P2164, DOI 10.1002/1521-4141(200107)31:7<2164::AID-IMMU2164>3.0.CO

[5]

2-S

[6]

Kim JM, 2002, CANCER RES, V62, P4212

[7]

Kur J, 2005, ACTA BIOCHIM POL, V52, P569

[8] Bcl11a is essential for normal lymphoid development [J].

Liu, PT ;

Keller, JR ;

Ortiz, M ;

Tessarollo, L ;

Rachel, RA ;

Nakamura, T ;

Jenkins, NA ;

Copeland, NG .

NATURE IMMUNOLOGY, 2003, 4 (06) :525-532

[9] Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells [J].

Melchers, F ;

ten Boekel, E ;

Seidl, T ;

Kong, XC ;

Yamagami, T ;

Onishi, K ;

Shimizu, T ;

Rolink, AG ;

Andersson, J .

IMMUNOLOGICAL REVIEWS, 2000, 175 :33-46

[10] Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy [J].

Miyamoto, S ;

Yagi, H ;

Yotsumoto, F ;

Kawarabayashi, T ;

Mekada, E .

CANCER SCIENCE, 2006, 97 (05) :341-347

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