Collagen Wound Dressings with Anti-Inflammatory Activity

被引：42

作者：

Albu, M. G. ^{[1
,2
]}

Ferdes, M. ^{[2
]}

Kaya, D. A. ^{[3
]}

Ghica, M. V. ^{[4
]}

Titorencu, I. ^{[5
]}

Popa, L. ^{[4
]}

Albu, L. ^{[6
]}

机构：

[1] Univ Agr Sci & Vet Med Cluj Napoca, Cluj Napoca, Romania

[2] Univ Politehn Bucuresti, Bucharest, Romania

[3] Mustafa Kemal Univ, Fac Agr, Antakya, Turkey

[4] Univ Med & Pharm Carol Davila, Fac Pharm, Bucharest, Romania

[5] Inst Cellular Biol & Pathol Nicolae Simionescu, Bucharest, Romania

[6] Leather & Footwear Res Inst, Bucharest, Romania

来源：

MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2012年 / 555卷

关键词：

Collagen; fibroblast cells; niflumic acid; scaffolds; wound dressing; DELIVERY;

D O I：

10.1080/15421406.2012.635556

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The aim of this study was to develop modern wound dressings such as controlled drug delivery systems. These systems consist in collagen as release support and niflumic acid as drug. The scaffolds were prepared by lyophilization in order to obtain porous structures and were evaluated by release profile of niflumic acid, water absorption, collagenase degradation and biocompatibility with fibroblast cells. The collagen scaffold with 0.75% niflumic acid solved in laurel oil was optimal in terms of biodegradability, absorbability and fibroblast cells biocompatibility. Thus, the obtained collagen scaffolds could be used as wound dressings with absorbent, antibacterial and anti-inflammatory properties.

引用

页码：271 / 279

页数：9

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