Novel polyacetylenes from Coreopsis tinctoria Nutt.

被引：27

作者：

Liu, Yan ^{[1
]}

Du, Dan ^{[1
]}

Liang, Yong ^{[1
]}

Xin, Guang ^{[1
]}

Huang, Bao-Zhan ^{[1
]}

Huang, Wen ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, West China Med Sc,Lab Ethnopharmacol, Regenerat Med Res Ctr,Inst Nanobiomed Technol & M, Chengdu 610041, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2015年 / 17卷 / 07期

基金：

中国博士后科学基金;

关键词：

Coreopsis tinctoria; polyacetylene; structure elucidation; anti-proliferation; anti-inflammation; ANTHOCHLOR PIGMENTS; FLAVONOIDS;

D O I：

10.1080/10286020.2014.996138

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Phytochemical investigation of the 95% EtOH extract of Coreopsis tinctoria Nutt. resulted in the isolation of two novel polyacetylenes, (2S)-(3Z,11E)-decadiene-5,7,9-triyne-1,2-diol (1) and (2R)-(3E,11Z)-decadiene-5,7,9-triyne-1,2-diol (2), together with two known polyacetylenes (3 and 4). The structures of these novel compounds were determined by extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. Compounds 1, 2, and 4 were evaluated for their anti-proliferative activities against C26 cell growth and inhibitory effects on the lipo-poly-saccharides-induced nitric oxide production using murine macrophage RAW 264.7 cells. However, compounds 1, 2, and 4 just showed weak activities.

引用

页码：744 / 749

页数：6

共 18 条

[1]

Phenolic compounds from the flowers of Coreopsis tinctoria [J].