Fibrin-polyethylene oxide interpenetrating polymer networks: New self-supported biomaterials combining the properties of both protein gel and synthetic polymer

被引：31

作者：

Akpalo, E. ^{[1
,2
]}

Bidault, L. ^{[1
,2
]}

Boissiere, M. ^{[2
]}

Vancaeyzeele, C. ^{[1
]}

Fichet, O. ^{[1
]}

Larreta-Garde, V. ^{[2
]}

机构：

[1] Cergy Pontoise Univ, Inst Mat, Lab Physicochim Polymeres & Interfaces LPPI, F-95000 Cergy Pontoise, France

[2] Cergy Pontoise Univ, Inst Mat, Equipe Rech Relat Matrice Extracellulaire Cellule, F-95000 Cergy Pontoise, France

来源：

ACTA BIOMATERIALIA | 2011年 / 7卷 / 06期

关键词：

Interpenetrating polymer network; Fibrin; Polyethylene Oxide; Biogel; Biomaterial; HYDROGELS; CLOT; ELASTICITY; DELIVERY; PEPTIDE; MATRIX; PRO;

D O I：

10.1016/j.actbio.2011.03.002

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Interpenetrating polymer network (IPN) architectures were conceived to improve the mechanical properties of a fibrin gel. Conditions allowing an enzymatic reaction to create one of the two networks in IPN architecture were included in the synthesis pathway. Two IPN series were carried out, starting from two polyethylene oxide (PEO) network precursors leading to different cross-linking densities of the PEO phase. The fibrin concentration varied from 5 to 20 wt.% in each series. The behavior of these materials during dehydration/hydration cycles was also studied. The mechanical properties of the resulting IPN were characterized in the wet and dry states. These self-supported biomaterials combine the properties of both a protein gel and a synthetic polymer. Finally, cells were grown on PEO/fibrin IPN, indicating that they are non-cytotoxic. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：2418 / 2427

页数：10

共 36 条

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Increase of fibrin gel elasticity by enzymes: A kinetic approach [J].