A novel AF9 breakpoint in MLL-AF9-positive acute monoblastic leukemia

被引：6

作者：

Alonso, Cristina N. ^{[1
]}

Longo, Patricia L. Rubio ^{[1
]}

Gallego, Marta S. ^{[2
]}

Medina, Adriana ^{[1
]}

Felice, Maria S. ^{[1
]}

机构：

[1] Hosp Pediat SAMIC Prof Dr JP Garrahan, Mol Biol Lab, Buenos Aires, DF, Argentina

[2] Hosp Pediat SAMIC Prof Dr JP Garrahan, Cytogenet Lab, Dept Genet, Buenos Aires, DF, Argentina

来源：

PEDIATRIC BLOOD & CANCER | 2008年 / 50卷 / 04期

关键词：

AML; infant; MLL-AF9; MLLT3; novel breakpoint; t(9; 11);

D O I：

10.1002/pbc.21393

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

MLL-AF9 is the most frequent MLL rearrangement in childhood acute myeloid leukemia (AML) and it may be also found in acute lymphoblastic leukemia (ALL) of patients younger than 1-year-old (infants). We report a novel AF9 breakpoint site, located between previously reported sites A and B, detected in an infant who was diagnosed with AML-FAB M5. The Occurrence of this new breakpoint should be considered when designing RT-PCR assays for the screening of MLL abnormalities. The precise characterization of the MLL-AF9 transcript is important to carry out the minimal residual disease analysis during the follow-up of the patients.

引用

页码：869 / 871

页数：3

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