Endogenous ligands of PPAR-γ reduce the liver injury in haemorrhagic shock

被引：34

作者：

Collin, M ^{[1
]}

Abdelrahman, M ^{[1
]}

Thiemermann, C ^{[1
]}

机构：

[1] St Bartholomews & Royal London Sch Med & Dent, William Harvey Res Inst, Dept Expt Med & Nephrol, London EC1M 6BQ, England

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 486卷 / 02期

基金：

芬兰科学院;

关键词：

shock; PPAR (peroxisome proliferator-activated receptor); GW9662;

D O I：

10.1016/j.ejphar.2003.12.032

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We demonstrate here for the first time that the novel, potent peroxisome proliferator-activated receptor (PPAR)-gamma antagonist GW9662 (2-chloro-5-nitrobenzanilide) augments the degree of liver injury associated with haemorrhagic (haemorrhage for 90 min and resuscitation for 4 h), but not endotoxic (6 mg/kg E. coli endotoxin i.v. for 6 h) shock in the anaesthetised rat. Thus, endogenous ligands for PPAR-gamma are released in haemorrhagic, but not endotoxic, shock in sufficient amounts to protect against injury. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：233 / 235

页数：3

共 7 条

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[2] The PPAR-γ ligand 15-deoxyΔ12,14 prostaglandin J2 reduces the liver injury in endotoxic shock [J].