An efficient strategy for the iterative synthesis of a trans-fused polytetrahydropyran ring system via SmI2-induced reductive intramolecular cyclization

被引:103
作者
Hori, N [1 ]
Matsukura, H [1 ]
Matsuo, G [1 ]
Nakata, T [1 ]
机构
[1] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan
关键词
samarium diiodide; radical reaction; cyclization; tetrahydropyrans;
D O I
10.1016/S0040-4039(99)00301-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A highly efficient strategy for the iterative synthesis of a trans-fused polytetrahydropyran ring system was developed. The new iterative method involves SmI2-induced reductive intramolecular cyclization of an aldehyde and a beta-alkoxy acrylate as the key step, producing a 2,3-trans-tetrahydropyran ring. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2811 / 2814
页数:4
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