How mesenchymal stem cells interact with tissue immune responses

被引：480

作者：

Shi, Yufang ^{[1
,2
]}

Su, Juanjuan ^{[1
]}

Roberts, Arthur I. ^{[2
]}

Shou, Peishun ^{[1
]}

Rabson, Arnold B. ^{[2
]}

Ren, Guangwen ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol,Inst Hlth Sci,Sch Med, Shanghai 200030, Peoples R China

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, New Brunswick, NJ 08901 USA

来源：

TRENDS IN IMMUNOLOGY | 2012年 / 33卷 / 03期

基金：

美国国家卫生研究院;

关键词：

VERSUS-HOST-DISEASE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ANTIINFLAMMATORY PROTEIN TSG-6; COLLAGEN-INDUCED ARTHRITIS; PROLIFERATION IN-VITRO; SUPPRESS T-LYMPHOCYTE; STROMAL CELLS; NITRIC-OXIDE; DENDRITIC CELLS; IFN-GAMMA;

D O I：

10.1016/j.it.2011.11.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mesenchymal stem cells (MSCs), also called multipotent mesenchymal stromal cells, exist in almost all tissues and are a key cell source for tissue repair and regeneration. Under pathological conditions, such as tissue injury, these cells are mobilized towards the site of damage. Tissue damage is usually accompanied by proinflammatory factors, produced by both innate and adaptive immune responses, to which MSCs are known to respond. Indeed, recent studies have shown that there are bidirectional interactions between MSCs and inflammatory cells, which determine the outcome of MSC-mediated tissue repair processes. Although many details of these interactions remain to be elucidated, we provide here a synthesis of the current status of this newly emerging and rapidly advancing field.

引用

页码：136 / 143

页数：8

共 99 条

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