Regioselective and enantiospecific rhodium-catalyzed allylic amination with N-(arylsulflonyl)anilines

被引:80
作者
Evans, PA [1 ]
Robinson, JE
Moffett, KK
机构
[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA
[2] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA
关键词
D O I
10.1021/ol016467b
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] The regioselective and enantiospecific rhodium-catalyzed allylic amination of secondary allylic carbonates 1 with N-(arylsulfonyl)anilines provides a convenient process for the construction of arylamines 2. This method, in conjunction with ring-closing metathesis and radical cyclization reactions, allows the direct construction of biologically relevant pharmacophores as exemplified by the construction of dihydroquinoline and dihydrobenzo[b]indoline derivatives.
引用
收藏
页码:3269 / 3271
页数:3
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