A stromal gene signature associated with inflammatory breast cancer

被引:131
作者
Boersma, Brenda J. [1 ]
Reimers, Mark [2 ]
Yi, Ming [3 ]
Ludwig, Joseph A. [2 ,4 ]
Luke, Brain T. [3 ]
Stephens, Robert M. [3 ]
Yfantis, Harry G. [5 ]
Lee, Dong H. [5 ]
Weinstein, John N. [2 ]
Ambs, Stefan [1 ]
机构
[1] NCI, Human Carcinogenesis Lab, Natl Inst Hlth, Ctr Canc Res, Bethesda, MD 20892 USA
[2] NCI, Natl Inst Hlth, Ctr Canc Res,Lab Mol Pharmacol, Genom & Bioinformat Grp, Bethesda, MD 20892 USA
[3] NCI Frederick SAIC Frederick Inc, Adv Biomed Comp Ctr, Frederick, MD USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Sarcoma Med Oncol, Houston, TX USA
[5] Baltimore Vet Affairs Med Ctr, Baltimore, MD USA
关键词
inflammatory breast cancer; stroma; gene signature; prediction;
D O I
10.1002/ijc.23237
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The factors that determine whether a breast carcinoma will develop into inflammatory breast cancer (IBC) remain poorly understood. Recent evidence indicates that the tumor stroma influences cancer phenotypes. We tested the hypotheses that the gene expression signature of the tumor stroma is a distinctive feature of IBC. We used laser capture microdissection to obtain enriched populations of tumor epithelial cells and adjacent stromal cells from 15 patients with IBC and 35 patients with invasive, noninflammatory breast cancer (non-IBC). Their mRNA expression profiles were assessed using Affymetrix GeneChips(TM). In addition, a previously established classifier for IBC was evaluated for the resulting data sets. The gene expression profile of the tumor stroma distinguished IBC from non-IBC, and a previously established IBC prediction signature performed better in classifying IBC using the gene expression profile of the tumor stroma than it did using the profile of the tumor epithelium. In a pathway analysis, the genes differentially expressed between IBC and non-IBC tumors clustered in distinct pathways. We identified multiple pathways related to the endoplasmic stress response that could be functionally significant in IBC. Our findings suggest that the gene expression in the tumor stroma may play a role in determining the IBC phenotype. (C) 2007 Wiley-Liss, Inc.
引用
收藏
页码:1324 / 1332
页数:9
相关论文
共 56 条
  • [1] Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers
    Armes, JE
    Hammet, F
    de Silva, M
    Ciciulla, J
    Ramus, SJ
    Soo, WK
    Mahoney, A
    Yarovaya, N
    Henderson, MA
    Gish, K
    Hutchins, AM
    Price, GR
    Venter, DJ
    [J]. ONCOGENE, 2004, 23 (33) : 5697 - 5702
  • [2] Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated protein
    Ballif, BA
    Mincek, NV
    Barratt, JT
    Wilson, ML
    Simmons, DL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) : 5544 - 5549
  • [3] Gene expression profiling identifies molecular subtypes of inflammatory breast cancer
    Bertucci, F
    Finetti, P
    Rougemont, J
    Charafe-Jauffret, E
    Cervera, N
    Tarpin, C
    Nguyen, C
    Xerri, L
    Houlgatte, M
    Jacquemier, J
    Viens, P
    Birnbaum, D
    [J]. CANCER RESEARCH, 2005, 65 (06) : 2170 - 2178
  • [4] Gene expression profiling for molecular characterization of inflammatory breast cancer and prediction of response to chemotherapy
    Bertucci, F
    Finetti, P
    Rougemont, J
    Charafe-Jauffret, E
    Nasser, V
    Loriod, W
    Camerlo, J
    Tagett, R
    Tarpin, C
    Houvenaeghel, G
    Nguyen, C
    Maraninchi, D
    Jacquemier, J
    Houlgatte, R
    Birnbaum, D
    Viens, P
    [J]. CANCER RESEARCH, 2004, 64 (23) : 8558 - 8565
  • [5] Molecular profiling of inflammatory breast cancer:: Identification of a poor-prognosis gene expression signature
    Bièche, I
    Lerebours, F
    Tozlu, S
    Espie, M
    Marty, M
    Lidereau, R
    [J]. CLINICAL CANCER RESEARCH, 2004, 10 (20) : 6789 - 6795
  • [6] SEL1L a multifaceted protein playing a role in tumor progression
    Biunno, Ida
    Cattaneo, Monica
    Orlandi, Rosaria
    Canton, Cristina
    Biagiotti, Laura
    Ferrero, Stefano
    Barberis, Massimo
    Pupa, Serenella M.
    Scarpa, Aldo
    Menard, Sylvie
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2006, 208 (01) : 23 - 38
  • [7] Association of breast cancer outcome with status of p53 and MDM2 SNP309
    Boersma, Brenda J.
    Howe, Tiffany M.
    Goodman, Julie E.
    Yfantis, Harry G.
    Lee, Dong H.
    Chanock, Stephen J.
    Ambs, Stefan
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (13) : 911 - 919
  • [8] Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
    Chang, HY
    Nuyten, DSA
    Sneddon, JB
    Hastie, T
    Tibshirani, R
    Sorlie, T
    Dai, HY
    He, YDD
    van't Veer, LJ
    Bartelink, H
    van de Rijn, M
    Brown, PO
    van de Vijver, MJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (10) : 3738 - 3743
  • [9] Chang S, 1998, CANCER, V82, P2366
  • [10] Inflammation and cancer
    Coussens, LM
    Werb, Z
    [J]. NATURE, 2002, 420 (6917) : 860 - 867