Simian virus 40 is present in human lymphomas and normal blood

被引：56

作者：

David, H ^{[1
]}

Mendoza, S ^{[1
]}

Konishi, T ^{[1
]}

Miller, CW ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Dept Med,Div Hematol Oncol, Los Angeles, CA 90048 USA

来源：

CANCER LETTERS | 2001年 / 162卷 / 01期

关键词：

Simian virus 40; lymphoma; lymphocyte; leukemia;

D O I：

10.1016/S0304-3835(00)00628-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many independent studies have demonstrated Simian virus 40 (SV40) in normal and neoplastic human tissues. Clonal integration of virus in the DNA of several thyroid and bone tumors suggests a direct role for SV40 in some cancers. However, in most cases the role of SV40 remains unclear. This study determined the presence of SV40, by amplification followed by hybridization, in 266 normal and neoplastic blood and lymphoid samples. Amplification detected SV40 in 14% of non-auto immune deficiency syndrome (AIDS) lymphomas, 28% of AIDS related lymphoma and 16% of peripheral blood lymphocytes from non-cancerous patients. No SV40 was detected in leukemia samples. Direct Southern blotting of SV40(+) samples detected no virus, consistent with less than one viral genome in ten cells. Sequence analysis of SV40 in blood and lymphoid samples found sequences distinct from laboratory strains of SV40. The presence of limited quantities of SV40 in a small proportion of both normal and neoplastic tissues is suggestive an adventitious presence with no apparent direct role in blood and lymphoid cancers. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：57 / 64

页数：8

共 37 条

[1]

Berenson JR, 1999, SEMIN ONCOL, V26, P2

[2] DNA-SEQUENCES SIMILAR TO THOSE OF SIMIAN VIRUS-40 IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS OF CHILDHOOD [J].