Chemotherapy response evaluation with FDG-PET in patients with colorectal cancer

被引：89

作者：

de Geus-Oei, L. F. ^{[1
]}

van Laarhoven, H. W. M. ^{[2
]}

Visser, E. P. ^{[1
]}

Hermsen, R. ^{[1
]}

van Hoorn, B. A. ^{[1
]}

Kamm, Y. J. L. ^{[2
]}

Krabbe, P. F. M. ^{[3
]}

Corstens, F. H. M. ^{[1
]}

Punt, C. J. A. ^{[2
]}

Oyen, W. J. G. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Nucl Med, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Med Technol Assessment, NL-6500 HB Nijmegen, Netherlands

来源：

ANNALS OF ONCOLOGY | 2008年 / 19卷 / 02期

关键词：

chemotherapy response monitoring; colorectal cancer; F-18-fluorodeoxyglucose-positron emission tomography (FDG-PET); patlak analysis (MRGlu); standardized uptake value (SUV); POSITRON-EMISSION-TOMOGRAPHY; LIVER METASTASES; RECTAL-CANCER; TUMOR RESPONSE; RADIOFREQUENCY ABLATION; PREOPERATIVE RADIATION; F-18-FDG PET; THERAPY; FLUORODEOXYGLUCOSE; PREDICTION;

D O I：

10.1093/annonc/mdm470

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The aim of this prospective study was to evaluate the value of F-18-fluorodeoxyglucose-positron emission tomography (FDG-PET) for early assessment of chemotherapy response in patients with advanced colorectal cancer. Methods: Dynamic FDG-PET was carried out before and at 2 (n = 50) and 6 months (n = 19) after the start of treatment. Quantitative Patlak analysis [metabolic rate of glucose (MRGlu)] and a simplified method to measure glucose metabolism [standardized uptake value (SUV)] were evaluated. The predictive value of changes in glucose metabolism was assessed with Cox proportional regression analysis. Overall survival (OS) and progression-free survival (PFS) were calculated using Kaplan-Meier estimates. Results: There was an increase in the rates of death (P = 0.049 for Delta MRGlu PET1-2; P = 0.017 for Delta SUV PET1-2; P = 0.032 for Delta MRGlu PET1-3; P = 0.048 for Delta SUV PET1-3) and progression (P = 0.026 for Delta MRGlu PET1-2; P = 0.035 for Delta SUV PET1-2; P = 0.041 for Delta MRGlu PET1-3; P = 0.081 for Delta SUV PET1-3) associated with worse response as assessed by PET on Cox proportional regression analysis. The OS and PFS analysis showed a significant predictive value at broad ranges of Delta MRGlu and Delta SUV cut-off levels. Conclusion: The degree of chemotherapy-induced changes in tumor glucose metabolism is highly predictive for patient outcome. The use of FDG-PET for therapy monitoring seems clinically feasible since simplified methods (SUV) are sufficiently reliable.

引用

页码：348 / 352

页数：5

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