Endothelial function is impaired in fit young adults of low birth weight

被引:136
作者
Goodfellow, J
Bellamy, MF
Gorman, ST
Brownlee, M
Ramsey, MW
Lewis, MJ
Davies, DP
Henderson, AH
机构
[1] Univ Wales Coll Med, Cardiovasc Sci Res Grp, Cardiff CF4 4XN, S Glam, Wales
[2] Univ Wales Coll Med, Dept Child Hlth, Cardiff CF4 4XN, S Glam, Wales
关键词
low birth weight; endothelial function; hypertension; diabetes; atheroma; coronary artery disease; insulin resistance;
D O I
10.1016/S0008-6363(98)00197-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Non-insulin-dependent diabetes, hypertension and ischaemic heart disease, with insulin resistance, are associated with low birch weight (the 'Small Baby Syndrome'). Common to these adult clinical conditions is endothelial dysfunction. We tested the hypothesis that endothelial dysfunction could precede their development in those of low birth weight. Methods: Endothelial function was measured by ultrasonic 'wall-tracking' of how-related brachial artery dilatation in fit 19-20 year old subjects randomly selected (blind to the investigators throughout the study) from low (<2.5 kg) and normal (3.0-3.8 kg) birth weight subjects in the 1975-7 cohort of the Cardiff Births Survey and with no known cause for endothelial dysfunction. Results: Flow-related dilatation was impaired in low birth weight relative to normal birth weight subjects (median 0.04 mm [1.5%] [n =22] cf. 0.11 mm [4.1%] [n= 17], p<0.05; 0.04 mm [1.5%] [n= 15] cf. 0.12 mm [4.4%] [n=12], p <0.05 after exclusion of inadvertently included ever-smokers). Conclusion: The findings suggest that endothelial dysfunction is a consequence of foetal malnutrition, consistent with contributing to the clinical features of the 'Small Baby Syndrome' in later adult life. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:600 / 606
页数:7
相关论文
共 60 条
[1]  
Adams M., 1996, Journal of Vascular Investigation, V2, P146
[2]   FETAL ORIGINS OF CORONARY HEART-DISEASE [J].
BARKER, DJP .
BRITISH MEDICAL JOURNAL, 1995, 311 (6998) :171-174
[3]  
BARKER DJP, 1986, LANCET, V1, P1077
[4]   SKELETAL-MUSCLE BLOOD-FLOW - A POSSIBLE LINK BETWEEN INSULIN RESISTANCE AND BLOOD-PRESSURE [J].
BARON, AD ;
BRECHTELHOOK, G ;
JOHNSON, A ;
HARDIN, D .
HYPERTENSION, 1993, 21 (02) :129-135
[5]  
Bones C. H., 1997, European Heart Journal, V18, P265
[6]  
BOTKER HE, 1993, LANCET, V342, P136
[7]  
CEJKA J, 1982, CLIN CHEM, V28, P1356
[8]   NONINVASIVE DETECTION OF ENDOTHELIAL DYSFUNCTION IN CHILDREN AND ADULTS AT RISK OF ATHEROSCLEROSIS [J].
CELERMAJER, DS ;
SORENSEN, KE ;
GOOCH, VM ;
SPIEGELHALTER, DJ ;
MILLER, OI ;
SULLIVAN, ID ;
LLOYD, JK ;
DEANFIELD, JE .
LANCET, 1992, 340 (8828) :1111-1115
[9]   ISLET FUNCTION IN OFFSPRING OF MOTHERS ON LOW-PROTEIN DIET DURING GESTATION [J].
DAHRI, S ;
SNOECK, A ;
REUSENSBILLEN, B ;
REMACLE, C ;
HOET, JJ .
DIABETES, 1991, 40 :115-120
[10]  
DEAN JD, 1991, LANCET, V337, P456