Cerebrospinal fluid selenium and chromium levels in patients with Parkinson's disease

被引:42
作者
Aguilar, MV
Jiménez-Jiménez, FJ
Molina, JA
Meseguer, I
Mateos-Vega, CJ
González-Muñoz, MJ
de Bustos, F
Gómez-Escalonilla, C
Ortí-Pareja, M
Zurdo, M
Martínez-Para, MC
机构
[1] Univ Alcala de Henares, Fac Pharm, Dept Nutr & Bromatol, Madrid, Spain
[2] Hosp Univ Principe Asturias, Dept Neurol, Madrid, Spain
[3] Hosp Univ Doce Octubre, Dept Neurol, Madrid, Spain
[4] Hosp Univ Doce Octubre, Dept Biochem, Madrid, Spain
关键词
Parkinson's disease; selenium; chromium; cerebrospinal fluid levels; serum levels;
D O I
10.1007/s007020050127
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We compared CSF and serum levels of selenium and chromium, measured by atomic absorption spectrophotometry, in 28 patients with Parkinson's disease (PD) and 43 matched controls. The CSF and serum levels of these trace metals did not differ significantly between PD patients and controls. CSF selenium and chromium levels were not correlated with age, age at onset? duration of the disease, scores of the Unified Parkinson Disease Rating Scale of the Hoehn and Yahr staging in the PD group. Although antiparkinsonian therapy did not influence significantly the CSF levels of selenium, PD patients not treated with levodopa had significantly higher CSF selenium levels than controls (p < 0.01). It is possible that increased CSF selenium levels could indicate an attempt of protection against oxidative stress. The normality of CSF and serum chromium levels suggest that these values are not related with the risk for PD.
引用
收藏
页码:1245 / 1251
页数:7
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