Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells

被引：28

作者：

Milligan, S ^{[1
]}

Robinson, M ^{[1
]}

O'Donnell, E ^{[1
]}

Blackbourn, DJ ^{[1
]}

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Div Virol, Glasgow G11 5JR, Lanark, Scotland

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.78.5.2591-2596.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The response of Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) to inflammatory cytokine treatment of experimentally infected endothelial cells was investigated. The cytokines inhibited spontaneous KSHV lytic gene expression but not the level of infection. The data suggest that if inflammatory cytokines present in KS lesions contribute to KSHV pathogenesis, they do so in part by promoting latent KSHV infection of the endothelial cells.

引用

页码：2591 / 2596

页数：6

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