(+)-α-[11C]dihydro-tetrabenazine PET imaging in familial paroxysmal dystonic choreoathetosis

被引：10

作者：

Bohnen, NI

Albin, RL

Frey, KA

Fink, JK

机构：

[1] Univ Michigan, Sch Med, Dept Internal Med, Div Nucl Med, Ann Arbor, MI USA

[2] Univ Michigan, Sch Med, Dept Neurol, Ann Arbor, MI USA

[3] Vet Adm Med Ctr, Ctr Geriatr Res Educ & Clin, Ann Arbor, MI 48105 USA

来源：

NEUROLOGY | 1999年 / 52卷 / 05期

关键词：

D O I：

10.1212/WNL.52.5.1067

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Clinical observations suggest a disturbance of striatal dopaminergic function in familial paroxysmal dystonic choreoathetosis (PDC). The authors used PET with [C-11]dihydrotetrabenazine (DTBZ) to study striatal dopaminergic innervation in PDC. The results did not reveal abnormal DTBZ binding potential in PDC striatum. This suggests that dopaminergic abnormalities, if present, may be due to altered regulation of dopamine release or to postsynaptic mechanisms, rather than to an altered density of nigrostriatal innervation.

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页码：1067 / 1069

页数：3

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