Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes

被引：11

作者：

Gruson, Damien ^{[1
,2
]}

Ginion, Audrey ^{[1
,2
]}

Lause, Pascale ^{[1
,2
]}

Ketelslegers, Jean-Marie ^{[1
,2
]}

Thissen, Jean-Paul ^{[1
,2
]}

Bertrand, Luc ^{[1
,2
]}

机构：

[1] Catholic Univ Louvain, B-1200 Brussels, Belgium

[2] Clin Univ St Luc, Inst Rech Expt & Clin, B-1200 Brussels, Belgium

来源：

PEPTIDES | 2012年 / 33卷 / 02期

关键词：

BETA SUPERFAMILY MEMBER; HEART-FAILURE; SKELETAL-MUSCLE; HYPERTROPHY; ACTIVATION; MYOCARDIUM; MODEL; MASS;

D O I：

10.1016/j.peptides.2011.12.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Urotensin II (UII) and urocortin (UCN) are potent contributors to the physiopathology of heart failure. Our study investigated the effects of UII and UCN on the expression of myostatin (Mstn) in primary culture of adult cardiomyocytes. Adult rat cardiomyocytes were stimulated for 48 h with UII and UCN. Cell size and protein content were determined. Mstn gene expression was determined by real time quantitative polymerase chain reaction. Treatment with UII and UCN stimulates hypertrophy of adult cardiomyocytes. This effect was associated with a twofold increase of Mstn gene expression. We have established for the first time that the two hypertrophic peptides UII and UCN stimulate the expression of Mstn. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：351 / 353

页数：3

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