Fetal and maternal angiogenic/anti-angiogenic factors in normal and preeclamptic pregnancy

被引：28

作者：

Catarino, Cristina ^{[1
,2
]}

Rebelo, Irene ^{[2
]}

Belo, Luis ^{[2
]}

Rocha, Susana ^{[2
]}

Castro, Elisabeth B. ^{[2
]}

Patricio, Belmiro ^{[3
,4
]}

Quintanilha, Alexandre ^{[5
]}

Santos-Silva, Alice ^{[2
]}

机构：

[1] Univ Porto, Fac Farm, Serv Bioquim, IBMC, P-4099030 Oporto, Portugal

[2] Univ Porto, Fac Farm FFUP, P-4099030 Oporto, Portugal

[3] Univ Porto, Fac Med, P-4099030 Oporto, Portugal

[4] Hosp Sao Joao, Serv Obstet & Ginecol, Oporto, Portugal

[5] Univ Porto, ICBAS, P-4099030 Oporto, Portugal

来源：

GROWTH FACTORS | 2009年 / 27卷 / 06期

关键词：

Pregnancy; preeclampsia; PlGF; VEGF; sVEGFR-1; ENDOTHELIAL GROWTH-FACTOR; PLACENTA; EXPRESSION; SERUM; BLOOD; HYPERTENSION; DYSFUNCTION; BIOLOGY; CELLS; SFLT1;

D O I：

10.3109/08977190903184670

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Few studies evaluated angiogenic/anti-angiogenic factors and endothelial (dys) function in both maternal and umbilical cord blood (UCB) in preeclampsia (PE). We aimed to clarify the role of placental growth factor (PlGF), vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 1 (VEGFR-1) and tissue plasminogen activator (tPA), by evaluating them in maternal and UCB in 42 normal and 46 preeclamptic (PEc) cases. In PE, maternal and UCB PlGF were significantly lower; maternal VEGF, sVEGFR-1 and tPA were significantly higher. In UCB, sVEGFR-1 and tPA were significantly higher in PEc cases, while VEGF and PlGF were significantly lower. A significant correlation between maternal and UCB sVEGFR-1, and between sVEGFR-1 and tPA both in maternal and UCB, was observed in PEc cases. In maternal and UCB circulation in PE, a close interaction seems to exist between endothelial dysfunction and angiogenesis disturbance, and sVEGFR-1 seems to play a central role in those disturbances.

引用

页码：345 / 351

页数：7

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