Synergism between natural products and antibiotics against infectious diseases

被引：635

作者：

Hemaiswarya, Shanmugam ^{[1
]}

Kruthiventi, Anil Kumar ^{[2
]}

Doble, Mukesh ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Biotechnol, Madras 600036, Tamil Nadu, India

[2] Inst Life Sci, Div Med Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

PHYTOMEDICINE | 2008年 / 15卷 / 08期

关键词：

infectious diseases; antibiotic resistance; natural products; resistance modifying agents; synergy;

D O I：

10.1016/j.phymed.2008.06.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Antibiotics have been effective in treating infectious diseases, but resistance to these drugs has led to the emergence of new and the reemergence of old infectious diseases. One strategy employed to overcome these resistance mechanisms is the use of combination of drugs, such as beta-lactams together with beta-lactamase inhibitors. Several plant extracts have exhibited synergistic activity against microorganisms. This review describes in detail, the observed synergy and mechanism of action between natural products including flavonoids and essential oils and synthetic drugs in effectively combating bacterial, fungal and mycobacterial infections. The mode of action of combination differs significantly than that of the same drugs acting individually; hence isolating a single component may lose Its importance thereby simplifying the task of pharma industries. (c) 2008 Elsevier GmbH. All rights reserved.

引用

页码：639 / 652

页数：14

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