Genome-wide association study of vitamin D concentrations in Hispanic Americans: The IRAS Family Study

被引：56

作者：

Engelman, Corinne D. ^{[1
]}

Meyers, Kristin J. ^{[1
]}

Ziegler, Julie T. ^{[2
]}

Taylor, Kent D. ^{[3
]}

Palmer, Nicholette D. ^{[4
,5
]}

Haffner, Steven M. ^{[6
]}

Fingerlin, Tasha E. ^{[7
]}

Wagenknecht, Lynne E. ^{[2
]}

Rotter, Jerome I. ^{[3
]}

Bowden, Donald W. ^{[4
,5
]}

Langefeld, Carl D. ^{[2
]}

Norris, Jill M. ^{[7
]}

机构：

[1] Univ Wisconsin, Dept Populat Hlth Sci, Sch Med & Publ Hlth, Madison, WI 53726 USA

[2] Wake Forest Univ, Sch Med, Div Publ Hlth Sci, Winston Salem, NC 27157 USA

[3] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA

[4] Wake Forest Univ, Sch Med, Dept Biochem, Winston Salem, NC 27157 USA

[5] Wake Forest Univ, Sch Med, Ctr Human Genom, Winston Salem, NC 27157 USA

[6] Univ Texas Hlth Sci Ctr San Antonio, Div Clin Epidemiol, San Antonio, TX 78229 USA

[7] Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO 80045 USA

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2010年 / 122卷 / 04期

关键词：

Vitamin D; 25-Hydroxyvitamin D; 1,25-Dihydroxyvitamin D; Genome-wide association study; Hispanic; INSULIN-RESISTANCE ATHEROSCLEROSIS; QUANTITATIVE TRAIT LOCI; AFRICAN-AMERICANS; LINKAGE ANALYSIS; IDENTIFICATION; POLYMORPHISMS;

D O I：

10.1016/j.jsbmb.2010.06.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vitamin D deficiency is associated with many adverse health outcomes. There are several well established environmental predictors of vitamin D concentrations, yet studies of the genetic determinants of vitamin D concentrations are in their infancy Our objective was to conduct a pilot genome-wide association (GWA) study of 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin (1,25[OH](2)D) concentrations in a subset of 229 Hispanic subjects, followed by replication genotyping of 50 single nucleotide polymorphisms (SNPs) in the entire sample of 1190 Hispanics from San Antonio, Texas and San Luis Valley, Colorado. Of the 309,200 SNPs that met all quality control criteria, three SNPs in high linkage disequilibrium (LD) with each other were significantly associated with 1,25[OH](2)D (rs6680429, rs9970802, and rs10889028) at a Bonferroni corrected P-value threshold of 1.62 X 10(-7), however none met the threshold for 25[OH]D Of the 50 SNPs selected for replication genotyping, five for 25[OH]D (rs2806508, rs10141935, rs4778359, rs1507023, and rs9937918) and eight for 1,25[OH](2)D (rs6680429, rs1348864, rs4559029, rs12667374, rs7781309, rs10505337, rs2486443, and rs2154175) were replicated in the entire sample of Hispanics (P<0.01). In conclusion, we identified several SNPs that were associated with vitamin D metabolite concentrations in Hispanics. These candidate polymorphisms merit further investigation in independent populations and other ethnicities. (C) 2010 Elsevier Ltd. All rights reserved

引用

页码：186 / 192

页数：7

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