Engineering the perfect (bacterial) cancer therapy

被引：624

作者：

Forbes, Neil S. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Chem Engn, Amherst, MA 01003 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 11期

基金：

美国国家卫生研究院;

关键词：

ATTENUATED SALMONELLA-TYPHIMURIUM; ENTERICA-SEROVAR-TYPHIMURIUM; MURINE TUMOR-MODELS; ENZYME-PRODRUG THERAPY; ESCHERICHIA-COLI NISSLE-1917; POSITRON-EMISSION-TOMOGRAPHY; PROTEIN EXPRESSION THERAPY; GENE-THERAPY; IN-VIVO; TARGETING SALMONELLA;

D O I：

10.1038/nrc2934

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bacterial therapies possess many unique mechanisms for treating cancer that are unachievable with standard methods. Bacteria can specifically target tumours, actively penetrate tissue, are easily detected and can controllably induce cytotoxicity. Over the past decade, Salmonella, Clostridium and other genera have been shown to control tumour growth and promote survival in animal models. In this Innovation article I propose that synthetic biology techniques can be used to solve many of the key challenges that are associated with bacterial therapies, such as toxicity, stability and efficiency, and can be used to tune their beneficial features, allowing the engineering of 'perfect' cancer therapies.

引用

页码：784 / 793

页数：10

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