Characterization and distribution of neuropeptide Y in the brain of a caecilian amphibian

被引：16

作者：

Ebersole, TJ

Conlon, JM

Goetz, FW

Boyd, SK ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA

[2] Creighton Univ, Sch Med, Dept Biomed Sci, Ctr Regulatory Peptide, Omaha, NE 68178 USA

来源：

PEPTIDES | 2001年 / 22卷 / 03期

基金：

美国国家科学基金会;

关键词：

Typhlonectes natans; Gymnophiona; NPY gene; reproduction; pituitary;

D O I：

10.1016/S0196-9781(01)00334-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuropeptide Y (NPY) from the brain of an amphibian from the order Gymnophiona (the caecilian, Typhlonectes natans) was characterized. We cloned a 790 base pair cDNA encoding the caecilian NPY precursor. The open reading frame consisted of 291 bases, indicating an NPY precursor of 97 amino acids. B oth deduced and isolated NPY primary structures were Tyr- Pro- Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu(10) -Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Lys-Tyr(20) -Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu(30)-Ile-Thr-Arg-Gln-Arg-Tyr . NH2. In caecilian brain, we observed NPY immunoreactive cells within the medial pallium, basal forebrain, preoptic area, midbrain tegmentum and trigeminal nucleus. The prevalence of preoptic and hypothalamic terminal field staining supports the hypothesis that NPY controls pituitary function in this caecilian. (C) 2001 Elsevier Science Inc. All rights reserved.

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页码：325 / 334

页数：10

相关论文

共 62 条

[1] NEUROPEPTIDE-Y DISTRIBUTION IN HUMAN-BRAIN [J].

ADRIAN, TE ;

ALLEN, JM ;

BLOOM, SR ;

GHATEI, MA ;

ROSSOR, MN ;

ROBERTS, GW ;

CROW, TJ ;

TATEMOTO, K ;

POLAK, JM .

NATURE, 1983, 306 (5943) :584-586

[2] MOLECULAR-STRUCTURE OF MAMMALIAN NEUROPEPTIDE-Y - ANALYSIS BY MOLECULAR-CLONING AND COMPUTER-AIDED COMPARISON WITH CRYSTAL-STRUCTURE OF AVIAN HOMOLOG [J].

ALLEN, J ;

NOVOTNY, J ;

MARTIN, J ;

HEINRICH, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2532-2536

[3] DISTRIBUTION AND RELATIVE ABUNDANCE OF NEURONS IN THE PIGEON FOREBRAIN CONTAINING SOMATOSTATIN, NEUROPEPTIDE-Y, OR BOTH [J].

ANDERSON, KD ;

REINER, A .

JOURNAL OF COMPARATIVE NEUROLOGY, 1990, 299 (03) :261-282

[4] LOCALIZATION OF NEUROPEPTIDE Y-IMMUNOREACTIVE CELLS AND FIBERS IN THE BRAIN OF THE JAPANESE-QUAIL [J].

ASTE, N ;

VIGLIETTIPANZICA, C ;

FASOLO, A ;

ANDREONE, C ;

VAUDRY, H ;

PELLETIER, G ;

PANZICA, GC .

CELL AND TISSUE RESEARCH, 1991, 265 (02) :219-230

[5] STRONG EVOLUTIONARY CONSERVATION OF NEUROPEPTIDE-Y - SEQUENCES OF CHICKEN, GOLDFISH, AND TORPEDO-MARMORATA DNA CLONES [J].

BLOMQVIST, AG ;

SODERBERG, C ;

LUNDELL, I ;

MILNER, RJ ;

LARHAMMAR, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2350-2354

[6]

BRODIN L, 1989, J NEUROSCI, V9, P3428

[7]

CAILLIEZ D, 1987, ZOOL SCI, V4, P123

[8] Neuropeptide Y family of peptides:: Structure, anatomical expression, function, and molecular evolution [J].

Cerdá-Reverter, JM ;

Larhammar, D .

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 2000, 78 (03) :371-392

[9] CHARACTERIZATION OF MELANOTROPIN-RELEASE-INHIBITING FACTOR (MELANOSTATIN) FROM FROG BRAIN - HOMOLOGY WITH HUMAN NEUROPEPTIDE-Y [J].

CHARTREL, N ;

CONLON, JM ;

DANGER, JM ;

FOURNIER, A ;

TONON, MC ;

VAUDRY, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3862-3866

[10] IMMUNOHISTOCHEMICAL LOCALIZATION OF NEUROPEPTIDE-Y-LIKE SUBSTANCE IN THE BRAIN AND HYPOPHYSIS OF THE BROWN HAGFISH, PARAMYXINE-ATAMI [J].

CHIBA, A ;

HONMA, Y ;

OKA, S .

CELL AND TISSUE RESEARCH, 1993, 271 (02) :289-295

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