Serum platelet-activating factor acetylhydrolase activity: relationship with metabolic syndrome in women with history of gestational diabetes mellitus

被引：15

作者：

Derbent, Aysel ^{[1
]}

Kargili, Ayse ^{[2
]}

Koca, Cemile ^{[3
]}

Guemues, Ilknur Inegoel ^{[1
]}

Sevgili, Sema ^{[3
]}

Simavli, Serap ^{[1
]}

Karakurt, Feridun ^{[2
]}

Turhan, Nilguen Oeztuerk ^{[1
]}

机构：

[1] Fatih Univ, Sch Med, Dept Obstet & Gynecol, TR-06510 Ankara, Turkey

[2] Fatih Univ, Sch Med, Dept Endocrinol, TR-06510 Ankara, Turkey

[3] Fatih Univ, Sch Med, Dept Clin Biochem, TR-06510 Ankara, Turkey

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2011年 / 27卷 / 02期

关键词：

Gestational diabetes; metabolic syndrome; platelet-activating factor acetylhydrolase; gamma-glutaminyl transferase; PLASMA PAF-ACETYLHYDROLASE; GAMMA-GLUTAMYL-TRANSFERASE; CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; SUBCLINICAL INFLAMMATION; PHOSPHOLIPASE A(2); INSULIN-RESISTANCE; RISK-FACTOR; LIPOPROTEIN; MARKERS;

D O I：

10.3109/09513590.2010.487612

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Methods. The cross-sectional study included 36 women with history of GDM and 40 women with history of normal glucose tolerance in pregnancy (control group). Results. Compared to the controls, the GDM group had significantly higher mean values for serum glucose, insulin, HOMA-IR, triglyceride, GGT and plasma PAF-AH activity, and a statistically higher prevalence of MS. Within the GDM group, women diagnosed with MS had significantly higher PAF-AH activity than those without MS (p = 0.002). Conclusion. This is the first study to have shown that plasma PAF-AH activity and GGT levels may be significant for evaluating atherosclerosis risk and metabolic hepatic damage in women with history of GDM.

引用

页码：128 / 133

页数：6

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