Metformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunction

被引：30

作者：

Audia, Pat ^{[1
]}

Feinfeld, Donald A. ^{[1
]}

Dubrow, Alan ^{[1
]}

Winchester, James F. ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, New York, NY 10003 USA

来源：

CLINICAL TOXICOLOGY | 2008年 / 46卷 / 02期

关键词：

metformin; celecoxib; candesartan; lactic acidosis; acute kidney injury; pancreatitis;

D O I：

10.1080/15563650701355314

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Polypharmacy may lead to synergistic complications from the different medications. We report the case of a 50-year-old woman who was prescribed II drugs, including a diuretic, celecoxib, metformin, and candesartan, and who developed acute kidney dysfunction while on these drugs, manifesting as severe proteinuria, acute azotemia, hyperkalemia. The kidney injury caused the accumulation of metformin, leading to lactic acidosis and acute pancreatitis. Sodium bicarbonate hemodialysis not only improved the metabolic abnormalities but also hastened the removal of metformin.

引用

页码：164 / 166

页数：3

共 20 条

[1] Nephrotic syndrome and interstitial nephritis associated with celecoxib [J].