Identification of broad specificity P450CAM variants by primary screening against indole as substrate

被引：35

作者：

Çelik, A ^{[1
]}

Speight, RE ^{[1
]}

Turner, NJ ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 29期

关键词：

D O I：

10.1039/b506156c

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

High-throughput screening of cytochrome P450(CAM) libraries, for their ability to oxidise indole to indigo and indirubin, has resulted in the identification of variants with activity towards the structurally unrelated substrate diphenylmethane.

引用

页码：3652 / 3654

页数：3

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