Proteases and protease-activated receptors (PARs): Novel signals for pain

被引：13

作者：

Cenac, N ^{[1
]}

Vergnolle, N ^{[1
]}

机构：

[1] Univ Calgary, Dept Pharmacol & Therapeut, Calgary, AB T2N 4N1, Canada

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 06期

关键词：

D O I：

10.2174/1568026054367601

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The recent detection of protease-activated receptors (PARs) on neurons of the peripheral and central nervous systems suggests that PARs and proteases that activate them, might be involved in neuronal functions. Among those functions, a particular focus on nociception has attracted considerable interest. The present article summarizes recent research progress on proteases and PARs as nociceptive signaling molecules in the nervous system and presents them as exciting ne v targets for therapeutic intervention in pain.

引用

收藏

页码：569 / 576

页数：8

相关论文

共 63 条

[1] Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase [J].

Ait-Belgnaoui, A ;

Bradesi, S ;

Fioramonti, J ;

Theodorou, V ;

Bueno, L .

PAIN, 2005, 113 (1-2) :141-147

[2] Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia [J].

Amadesi, S ;

Nie, JJ ;

Vergnolle, N ;

Cottrell, GS ;

Grady, EF ;

Trevisani, M ;

Manni, C ;

Geppetti, P ;

McRoberts, JA ;

Ennes, H ;

Davis, B ;

Mayer, EA ;

Bunnett, NW .

JOURNAL OF NEUROSCIENCE, 2004, 24 (18) :4300-4312

[3] Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli [J].

Asfaha, S ;

Brussee, V ;

Chapman, K ;

Zochodne, DW ;

Vergnolle, N .

BRITISH JOURNAL OF PHARMACOLOGY, 2002, 135 (05) :1101-1106

[4] Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome [J].

Barbara, G ;

Stanghellini, V ;

De Giorgio, R ;

Cremon, C ;

Cottrell, GS ;

Santini, D ;

Pasquinelli, G ;

Morselli-Labate, AM ;

Grady, EF ;

Bunnett, NW ;

Collins, SM ;

Corinalidesi, R .

GASTROENTEROLOGY, 2004, 126 (03) :693-702

[5]

Bustos D, 1998, MEDICINA-BUENOS AIRE, V58, P262

[6] The capsaicin receptor: a heat-activated ion channel in the pain pathway [J].

Caterina, MJ ;

Schumacher, MA ;

Tominaga, M ;

Rosen, TA ;

Levine, JD ;

Julius, D .

NATURE, 1997, 389 (6653) :816-824

[7] PAR2 activation alters colonic paracellular permeability in mice via IFN-γ-dependent and -independent pathways [J].

Cenac, N ;

Chin, AC ;

Garcia-Villar, R ;

Salvador-Cartier, C ;

Ferrier, L ;

Vergnolle, N ;

Buret, AG ;

Fioramonti, J ;

Bueno, L .

JOURNAL OF PHYSIOLOGY-LONDON, 2004, 558 (03) :913-925

[8] Proteinase-activated receptor-2-induced colonic inflammation in mice: Possible involvement of afferent neurons, nitric oxide, and paracellular permeability [J].

Cenac, N ;

Garcia-Villar, R ;

Ferrier, L ;

Larauche, M ;

Vergnolle, N ;

Bunnett, NW ;

Coelho, AM ;

Fioramonti, J ;

Bueno, L .

JOURNAL OF IMMUNOLOGY, 2003, 170 (08) :4296-4300

[9] Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2 [J].

Cenac, N ;

Coelho, AM ;

Nguyen, C ;

Compton, S ;

Andrade-Gordon, P ;

MacNaughton, WK ;

Wallace, JL ;

Hollenberg, MD ;

Bunnett, NW ;

Garcia-Villar, R ;

Bueno, L ;

Vergnolle, N .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (05) :1903-1915

[10] Proteinases and proteinase-activated receptor 2: A possible role to promote visceral hyperalgesia in rats [J].

Coelho, AM ;

Vergnolle, N ;

Guiard, B ;

Fioramonti, J ;

Bueno, L .

GASTROENTEROLOGY, 2002, 122 (04) :1035-1047

← 1 2 3 4 5 6 7 →