A role for midbrain raphe γ aminobutyric acid neurons in 5-hydroxytryptamine feedback control

被引：31

作者：

Boothman, LJ ^{[1
]}

Sharp, T ^{[1
]}

机构：

[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England

来源：

NEUROREPORT | 2005年 / 16卷 / 09期

关键词：

c-fos; (+/-)-2,5-dimethoxy-4-iodoamphetamine (DOI); dorsal raphe nucleus (DRN); gamma-aminobutyric acid (GABA); 5-hydroxytryptamine (5-HT); 5-HT2; receptor;

D O I：

10.1097/00001756-200506210-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

New data show that 5-hydroxytryptamine (5-HT) neurons of the dorsal raphe nucleus (DRN) are subject to feedback control from 5-HT2 receptors, but the circuitry involved is uncertain. This study investigated whether 5-HT2 receptor agonism activates DRN gamma-aminobutyric acid (GABA) neurons, which are known to inhibit neighbouring 5-HT neurons. Systemic administration of the 5-HT2 receptor agonist, DOI, caused a striking increase in Fos-immunoreactivity in the DRN. This effect was abolished by the 5-HT2 antagonists ritanserin and MDL 100907, but not SB 206553, indicating the involvement of 5-HT2A receptors. Importantly, DOI-induced Fos-immunoreactivity in the DRN was extensively colocalized in GAD(67)-immunoreactive neurons. These findings suggest that activated local GABA neurons may play an important role in 5-HT2 receptor-mediated feedback control of DRN 5-HT neurons. NeuroReport 16:891-896 (c) 2005 Lippincott Williams & Wilkins.

引用

页码：891 / 896

页数：6

共 26 条

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