Heterogeneity of susceptibility to fluoroquinolones in Bartonella isolates from Australia reveals a natural mutation in gyrA
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作者:
Angelakis, Emmanouil
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Univ Aix Marseille 2, Fac Med & Pharm, CNRS UMR 6020,IFR 48, Unite Rickettsies, F-13385 Marseille 5, FranceUniv Aix Marseille 2, Fac Med & Pharm, CNRS UMR 6020,IFR 48, Unite Rickettsies, F-13385 Marseille 5, France
Angelakis, Emmanouil
[1
]
Biswas, Silpak
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Univ Aix Marseille 2, Fac Med & Pharm, CNRS UMR 6020,IFR 48, Unite Rickettsies, F-13385 Marseille 5, FranceUniv Aix Marseille 2, Fac Med & Pharm, CNRS UMR 6020,IFR 48, Unite Rickettsies, F-13385 Marseille 5, France
Biswas, Silpak
[1
]
Taylor, Carmel
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Publ Hlth Virol Forens & Sci Serv, Coopers Plains Q 4108, AustraliaUniv Aix Marseille 2, Fac Med & Pharm, CNRS UMR 6020,IFR 48, Unite Rickettsies, F-13385 Marseille 5, France
Taylor, Carmel
[2
]
Raoult, Didier
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Univ Aix Marseille 2, Fac Med & Pharm, CNRS UMR 6020,IFR 48, Unite Rickettsies, F-13385 Marseille 5, FranceUniv Aix Marseille 2, Fac Med & Pharm, CNRS UMR 6020,IFR 48, Unite Rickettsies, F-13385 Marseille 5, France
Raoult, Didier
[1
]
Rolain, Jean-Marc
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Univ Aix Marseille 2, Fac Med & Pharm, CNRS UMR 6020,IFR 48, Unite Rickettsies, F-13385 Marseille 5, FranceUniv Aix Marseille 2, Fac Med & Pharm, CNRS UMR 6020,IFR 48, Unite Rickettsies, F-13385 Marseille 5, France
Rolain, Jean-Marc
[1
]
机构:
[1] Univ Aix Marseille 2, Fac Med & Pharm, CNRS UMR 6020,IFR 48, Unite Rickettsies, F-13385 Marseille 5, France
Objectives: Bartonella sp. are intracellular bacteria associated with an increasing number of clinical manifestations but with few published data on in vitro susceptibility testing of antibiotics. Our objective was to evaluate in vitro antibiotic susceptibilities of 20 new Bartonella isolates from animals in Australia. Methods: MICs were determined using Etest assay on Columbia agar supplemented with 5% horse blood. The presence of mutations in the quinolone-resistance-determining region (QRDR) of gyrA was searched for after PCR amplification and DNA sequencing using specific oligonucleotide primers. Results: Bartonella isolates from Australia were susceptible to rifampicin, tetracyclines, beta-lactam and macrolide compounds but were resistant to vancomycin. We found heterogeneity of susceptibility for fluoroquinolones with ciprofloxacin being more effective (MICs from 0.06 to 0.5 mg/L) than ofloxacin (MICs from 0.5 to 4 mg/L). This heterogeneity was linked to a natural mutation Ser-83 -> Ala (Escherichia coli numbering) in the QRDR. Surprisingly, this mutation was also present in the QRDR of Bartonella henselae, Bartonella quintana and Bartonella bacilliformis. Conclusions: Etest is a sensitive and reliable assay for evaluation of antibiotic susceptibility in the genus Bartonella. The higher sensitivity of this method allowed us to detect heterogeneity of susceptibility among fluoroquinolones that was associated with natural mutation in the QRDR of the DNA gyrase. Because a high level of resistance to fluoroquinolones due to a second mutation may be obtained easily in vitro, we believe that fluoroquinolone compounds should be avoided for the treatment of any Bartonella-related diseases.
机构:
Univ Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, FranceUniv Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, France
Biswas, Silpak
Raoult, Didier
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机构:
Univ Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, FranceUniv Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, France
Raoult, Didier
Rolain, Jean-Marc
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机构:
Univ Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, FranceUniv Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, France
机构:
Univ Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, FranceUniv Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, France
Masselot, F
Boulos, A
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Univ Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, FranceUniv Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, France
Boulos, A
Maurin, M
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机构:
Univ Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, FranceUniv Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, France
Maurin, M
Rolain, JM
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Univ Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, FranceUniv Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, France
Rolain, JM
Raoult, D
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h-index: 0
机构:
Univ Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, FranceUniv Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, France
机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Meghari, S
Rolain, JM
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机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Rolain, JM
Grau, GE
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Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Grau, GE
Platt, E
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Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Platt, E
Barrassi, L
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Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Barrassi, L
Mège, JL
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机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Mège, JL
Raoult, D
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h-index: 0
机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
机构:
Univ Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, FranceUniv Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, France
Biswas, Silpak
Raoult, Didier
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h-index: 0
机构:
Univ Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, FranceUniv Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, France
Raoult, Didier
Rolain, Jean-Marc
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h-index: 0
机构:
Univ Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, FranceUniv Mediterranee, Fac Med & Pharm, CNRS UMR 6020, Unite Rickettsies,IFR 48, F-13385 Marseille 05, France
机构:
Univ Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, FranceUniv Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, France
Masselot, F
Boulos, A
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h-index: 0
机构:
Univ Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, FranceUniv Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, France
Boulos, A
Maurin, M
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h-index: 0
机构:
Univ Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, FranceUniv Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, France
Maurin, M
Rolain, JM
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h-index: 0
机构:
Univ Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, FranceUniv Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, France
Rolain, JM
Raoult, D
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机构:
Univ Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, FranceUniv Mediterranee, Unite Rickettsies, CNRS,Fac Med, UMR 6020,IFR48, F-13385 Marseille 05, France
机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Meghari, S
Rolain, JM
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h-index: 0
机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Rolain, JM
Grau, GE
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h-index: 0
机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Grau, GE
Platt, E
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h-index: 0
机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Platt, E
Barrassi, L
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h-index: 0
机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Barrassi, L
Mège, JL
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h-index: 0
机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France
Mège, JL
Raoult, D
论文数: 0引用数: 0
h-index: 0
机构:
Univ Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, FranceUniv Mediterranee, CNRS, UMR 6020, Unite Rickettsies,IFR 48,27 Bd Jean Moulin, F-13385 Marseille, France