Evidence for protein splicing in the endoplasmic reticulum-Golgi intermediate compartment

被引：5

作者：

Demirov, D

Sarafian, V

Kremensky, I

Ganev, V

机构：

[1] Med Univ Sofia, Dept Biochem & Chem, Lab Mol Biol & Genet, Sofia 1431, Bulgaria

[2] Higher Med Inst, Dept Biol, Plovdiv 4000, Bulgaria

[3] Med Univ Sofia, Lab Mol Pathol, Univ Hosp Obstet & Gynaecol, Sofia 1431, Bulgaria

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1999年 / 1448卷 / 03期

关键词：

endoplasmic reticulum Golgi intermediate compartment; protein splicing; protein sorting; cathepsin C;

D O I：

10.1016/S0167-4889(98)00158-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present evidence that the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is a site for protein splicing of cathepsin C: (i) maturation of the enzyme in COS 7 cells is a two-step process starting within the ERGIC, and (ii) the intermediately processed polypeptide retains both termini of the proenzyme and lacks an internal fragment. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：507 / 511

页数：5

共 13 条

[1] Protein splicing: Its chemistry and biology
Anraku, Y
[J]. GENES TO CELLS, 1997, 2 (06) : 359 - 367
[2] ALIGNMENT PHYLOGENY OF THE PAPAIN SUPERFAMILY OF CYSTEINE PROTEASES
BERTI, PJ
STORER, AC
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1995, 246 (02) : 273 - 283
[3] Stoichiometry and heterogeneity of the pro-region chain in tetrameric human cathepsin C
Cigic, B
Krizaj, I
Kralj, B
Turk, V
Pain, RH
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1998, 1382 (01): : 143 - 150
[4] DEMIROV D, 1998, IN PRESS ANAL BIOCH, V264
[5] OLIGOMERIC STRUCTURE AND SUBSTRATE-INDUCED INHIBITION OF HUMAN CATHEPSIN-C
DOLENC, I
TURK, B
PUNGERCIC, G
RITONJA, A
TURK, V
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (37) : 21626 - 21631
[6] ΔF508 CFTR localizes in the endoplasmic reticulum Golgi intermediate compartment in cystic fibrosis cells
Gilbert, A
Jadot, M
Leontieva, E
Wattiaux-De Coninck, S
Wattiaux, R
[J]. EXPERIMENTAL CELL RESEARCH, 1998, 242 (01) : 144 - 152
[7] HAURI H-P, 1992, Current Opinion in Cell Biology, V4, P600, DOI 10.1016/0955-0674(92)90078-Q
[8] SYNTHESIS, TRANSPORT AND PROCESSING OF CATHEPSIN-C IN MORRIS HEPATOMA 7777 CELLS AND RAT HEPATOCYTES
MAINFERME, F
WATTIAUX, R
VONFIGURA, K
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 153 (01): : 211 - 216
[9] PROCESSING AND TRANSPORT OF THE PRECURSOR OF CATHEPSIN-C DURING ITS TRANSFER INTO LYSOSOMES
MUNO, D
ISHIDOH, K
UENO, T
KOMINAMI, E
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 306 (01) : 103 - 110
[10] Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII
Nichols, WC
Seligsohn, U
Zivelin, A
Terry, VH
Hertel, CE
Wheatley, MA
Moussalli, MJ
Hauri, HP
Ciavarella, N
Kaufman, RJ
Ginsburg, D
[J]. CELL, 1998, 93 (01) : 61 - 70

← 1 2 →