DNA methylation in genomic imprinting, development, and disease

被引：263

作者：

Paulsen, M ^{[1
]}

Ferguson-Smith, AC ^{[1
]}

机构：

[1] Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England

来源：

JOURNAL OF PATHOLOGY | 2001年 / 195卷 / 01期

关键词：

imprinting; methylation; cancer; Beckwith-Wiedemann syndrome; Prader-Willi syndrome; Angelman syndrome;

D O I：

10.1002/path.890

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Changes in DNA methylation profiles are common features of development and in a number of human diseases, such as cancer and imprinting disorders like Beckwith-Wiedemann and Prader-Willi/Angelman syndromes. This suggests that DNA methylation is required for proper gene regulation during development and in differentiated tissues and has clinical relevance. DNA methylation is also involved in X-chromosome inactivation and the allele-specific silencing of imprinted genes. This review describes possible mechanisms by which DNA methylation can regulate gene expression, using imprinted genes as examples. The molecular basis of methylation-mediated gene regulation is related to changes in chromatin structure and appears to be similar for both imprinted and biallelically expressed genes. Copyright (C) 2001 John Wiley & Sons, Ltd.

引用

页码：97 / 110

页数：14

共 133 条

[1]

Adenot PG, 1997, DEVELOPMENT, V124, P4615

[2]

Ainscough JFX, 2000, DEVELOPMENT, V127, P3923

[3]

Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome [J].