Redox signaling of NF-κB by membrane NAD(P)H oxidases in normal and malignant cells

被引：29

作者：

Brar, SS

Kennedy, TP

Quinn, M

Hoidal, JR

机构：

[1] Carolinas Med Ctr, Dept Internal Med, Charlotte, NC 28232 USA

[2] Montana State Univ, Dept Vet Mol Biol, Bozeman, MT 59717 USA

[3] Univ Utah, Dept Med, Salt Lake City, UT 84112 USA

来源：

PROTOPLASMA | 2003年 / 221卷 / 1-2期

关键词：

NADPH oxidase; nuclear factor kappa B; NAD(P)H oxidase subunit p22(phox); NAD(P)H oxidase subunit gp91(phox); superoxide anion; melanoma;

D O I：

10.1007/s00709-002-0059-y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Evidence is rapidly accumulating that low-activity NAD(P)H oxidases homologous to that in phagocytic cells generate reactive oxygen species as signaling intermediates. In this review we discuss evidence that signaling NAD(P)H oxidases in part influence normal and malignant cell division by activating the redox-regulated transcription factor nuclear factor kappaB. The roles of growth-regulatory NAD(P)H oxidases in human airway smooth muscle and malignant melanoma are used as examples.

引用

收藏

页码：117 / 127

页数：11

相关论文

共 43 条

[1] Platelet-derived growth factor-induced H2O2 production requires the activation of phosphatidylinositol 3-kinase [J].

Bae, YS ;

Sung, JY ;

Kim, OS ;

Kim, YJ ;

Hur, KC ;

Kazlauskas, A ;

Rhee, SG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (14) :10527-10531

[2] Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB [J].

Baldwin, AS .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (03) :241-246

[3] Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells [J].

Bargou, RC ;

Emmerich, F ;

Krappmann, D ;

Bommert, K ;

Mapara, MY ;

Arnold, W ;

Royer, HD ;

Grinstein, E ;

Greiner, A ;

Scheidereit, C ;

Dörken, B .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (12) :2961-2969

[4] IκBα gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-α-mediated cell death [J].

Batra, RK ;

Guttridge, DC ;

Brenner, DA ;

Dubinett, SM ;

Baldwin, AS ;

Boucher, RC .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1999, 21 (02) :238-245

[5] I-KAPPA-B INTERACTS WITH THE NUCLEAR-LOCALIZATION SEQUENCES OF THE SUBUNITS OF NF-KAPPA-B - A MECHANISM FOR CYTOPLASMIC RETENTION [J].

BEG, AA ;

RUBEN, SM ;

SCHEINMAN, RI ;

HASKILL, S ;

ROSEN, CA ;

BALDWIN, AS .

GENES & DEVELOPMENT, 1992, 6 (10) :1899-1913

[6] EXPRESSION OF A CONSTITUTIVE NF-KAPPA-B-LIKE ACTIVITY IS ESSENTIAL FOR PROLIFERATION OF CULTURED BOVINE VASCULAR SMOOTH-MUSCLE CELLS [J].

BELLAS, RE ;

LEE, JS ;

SONENSHEIN, GE .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (05) :2521-2527

[7] THE NF-KAPPA-B TRANSCRIPTION FACTOR AND CANCER - HIGH EXPRESSION OF NF-KAPPA-B- AND I-KAPPA-B-RELATED PROTEINS IN TUMOR-CELL LINES [J].

BOURS, V ;

DEJARDIN, E ;

GOUJONLETAWE, F ;

MERVILLE, MP ;

CASTRONOVO, V .

BIOCHEMICAL PHARMACOLOGY, 1994, 47 (01) :145-149

[8] Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle [J].

Brar, SS ;

Kennedy, TP ;

Whorton, AR ;

Murphy, TM ;

Chitano, P ;

Hoidal, JR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (28) :20017-20026

[9] NADPH oxidase promotes NF-κB activation and proliferation in human airway smooth muscle [J].

Brar, SS ;

Kennedy, TP ;

Sturrock, AB ;

Huecksteadt, TP ;

Quinn, MT ;

Murphy, TM ;

Chitano, P ;

Hoidal, JR .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2002, 282 (04) :L782-L795

[10] Homologs of gp91phox:: cloning and tissue expression of Nox3, Nox4, and Nox5 [J].

Cheng, GJ ;

Cao, ZH ;

Xu, XX ;

Van Meir, EG ;

Lambeth, JD .

GENE, 2001, 269 (1-2) :131-140

← 1 2 3 4 5 →