Leiornyosarcoma of the bladder in a retinoblastoma patient

被引：12

作者：

Bléoo, SL

Godbout, R

Rayner, D

Tamimi, Y

Moore, RB

机构：

[1] Cross Canc Inst, Dept Surg, Edmonton, AB T6G 1Z2, Canada

[2] Cross Canc Inst, Dept Oncol, Edmonton, AB T6G 1Z2, Canada

[3] Cross Canc Inst, Dept Lab Med & Pathol, Edmonton, AB T6G 1Z2, Canada

[4] Univ Alberta, Edmonton, AB, Canada

来源：

UROLOGIA INTERNATIONALIS | 2003年 / 71卷 / 01期

关键词：

leiomyosarcoma; bladder cancer; retinoblastoma;

D O I：

10.1159/000071109

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report a rare case of leiomyosarcoma in the bladder which occurred in an 18-year-old female with a prior history of retinoblastoma (RB). Molecular characterization of this tumor displayed a homozygous RB deletion and a reduced p53 expression. These results suggest that the loss of RB and p53 may have contributed to the initiation and/or progression of the leiomyosarcoma of the bladder in this patient. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：118 / 121

页数：4

共 10 条

[1] DEFICIENCY OF RETINOBLASTOMA PROTEIN LEADS TO INAPPROPRIATE S-PHASE ENTRY, ACTIVATION OF E2F-RESPONSIVE GENES, AND APOPTOSIS [J].