The Effect of Testosterone Upon the Urate Reabsorptive Transport System in Mouse Kidney

被引：60

作者：

Hosoyamada, M. ^{[1
]}

Takiue, Y. ^{[1
]}

Shibasaki, T. ^{[1
]}

Saito, H. ^{[1
]}

机构：

[1] Keio Univ, Fac Pharm, Minato Ku, Tokyo 1058512, Japan

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2010年 / 29卷 / 07期

关键词：

Urate; transporter; kidney; testosterone; RENAL HYPOURICEMIA; GENE;

D O I：

10.1080/15257770.2010.494651

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

It is hypothesized that hyperuricemia in males is caused by androgen-induced urate reabsorptive transport system in the kidney. The expression of urate transporter 1 (Urat1), sodium-coupled monocarboxylate transporter 1 (Smct1) and glucose transporter 9 (Glut9) were investigated in orchiectomized mice with or without testosterone replacement. Testosterone enhanced mRNA and protein levels of Smct1 while those of Glut9 were attenuated. Although the mRNA level of Urat1 was enhanced by testosterone, the corresponding levels of Urat1 protein remained unaffected. Thus, the induction of Smct1 by testosterone is a candidate mechanism underlying hyperuricemia in males.

引用

页码：574 / 579

页数：6

共 15 条

[1]

ADAMOPOULOS D, 1977, ACTA ENDOCRINOL-COP, V85, P198

[2]

New insights into renal transport of urate [J].

Anzai, Naohiko ;

Kanai, Yoshikatsu ;

Endou, Hitoshi .

CURRENT OPINION IN RHEUMATOLOGY, 2007, 19 (02) :151-157

[3]

DARLINGTON LG, 1991, ADV EXP MED BIOL, V309, P235

[4]

Homozygous SLC2A9 Mutations Cause Severe Renal Hypouricemia [J].

Dinour, Dganit ;

Gray, Nicola K. ;

Campbell, Susan ;

Shu, Xinhua ;

Sawyer, Lindsay ;

Richardson, William ;

Rechavi, Gideon ;

Amariglio, Ninette ;

Ganon, Liat ;

Sela, Ben-Ami ;

Bahat, Hilla ;

Goldman, Michael ;

Weissgarten, Joshua ;

Millar, Michael R. ;

Wright, Alan F. ;

Holtzman, Eliezer J. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 21 (01) :64-72

[5]

Molecular identification of a renal urate-anion exchanger that regulates blood urate levels [J].

Enomoto, A ;

Kimura, H ;

Chairoungdua, A ;

Shigeta, Y ;

Jutabha, P ;

Cha, SH ;

Hosoyamada, M ;

Takeda, M ;

Sekine, T ;

Igarashi, T ;

Matsuo, H ;

Kikuchi, Y ;

Oda, T ;

Ichida, K ;

Hosoya, T ;

Shimokata, K ;

Niwa, T ;

Kanai, Y ;

Endou, H .

NATURE, 2002, 417 (6887) :447-452

[6]

HOSOYAMADA M, 2010, NNNA IN PRESS

[7]

Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion [J].

Ichida, K ;

Hosoyamada, M ;

Hisatome, I ;

Enomoto, A ;

Hikita, M ;

Endou, H ;

Hosoya, T .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (01) :164-173

[8]

Mouse glucose transporter 9 splice variants are expressed in adult liver and kidney and are up-regulated in diabetes [J].

Keembiyehetty, C ;

Augustin, R ;

Carayannopoulos, MO ;

Steer, S ;

Manolescu, A ;

Cheeseman, CI ;

Moley, KH .

MOLECULAR ENDOCRINOLOGY, 2006, 20 (03) :686-697

[9]

Molecular cloning and characterization of a human urate transporter (hURAT1) gene promoter [J].

Li, T ;

Walsh, JR ;

Ghishan, FK ;

Bai, LQ .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2004, 1681 (01) :53-58

[10]

Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition [J].

Ljubojevic, M ;

Herak-Kramberger, CM ;

Hagos, Y ;

Bahn, A ;

Endou, H ;

Burckhardt, G ;

Sabolic, I .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 287 (01) :F124-F138

← 1 2 →