Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways

被引:93
作者
Capili, Allan D. [1 ]
Lima, Christopher D. [1 ]
机构
[1] Sloan Kettering Inst, Struct Biol Program, New York, NY 10065 USA
关键词
D O I
10.1016/j.sbi.2007.08.018
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins regulate a diverse array of cellular pathways through post-translational attachment to protein substrates. Ub/Ubl-mediated signaling is initiated through E1, E2, and E3-mediated conjugation, transduced by proteins that recognize Ub/Ubl-modified substrates, and terminated by proteases which remove the Ub/Ubl from the substrate. Recent structural studies have elucidated mechanisms pertinent to Ub/Ubl conjugation, recognition, and deconjugation, highlighting essential steps during Ub/Ubl modification that illustrate common and divergent mechanistic themes within this important process.
引用
收藏
页码:726 / 735
页数:10
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[1]   Mechanism and function of deubiquitinating enzymes [J].
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1695 (1-3) :189-207
[2]   Crystal structure of thymine DNA glycosylase conjugated to SUMO-1 [J].
Baba, D ;
Maita, N ;
Jee, JG ;
Uchimura, Y ;
Saitoh, H ;
Sugasawa, K ;
Hanaoka, F ;
Tochio, H ;
Hiroaki, H ;
Shirakawa, M .
NATURE, 2005, 435 (7044) :979-982
[3]   Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1 [J].
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Matunis, MJ ;
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[4]   Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes [J].
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Melchior, F .
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[5]   Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction [J].
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[6]   Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation [J].
Eddins, Michael J. ;
Carlile, Candice M. ;
Gomez, Kamila M. ;
Pickart, Cecile M. ;
Wolberger, Cynthia .
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[7]   Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail [J].
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Ellison, MJ ;
Barber, KR ;
Williams, RS ;
Huzil, JT ;
McKenna, S ;
Ptak, C ;
Glover, M ;
Shaw, GS .
STRUCTURE, 2001, 9 (10) :897-904
[8]   Structure of a Fbw7-Skp1-cyclin E complex: Multisite-phosphorylated substrate recognition by SCF ubiquitin ligases [J].
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[9]   Structural complexity in ubiquitin recognition [J].
Harper, JW ;
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[10]   The ubiquitin system [J].
Hershko, A ;
Ciechanover, A .
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