Absence of N-acetylaspartate in the human brain:: Impact on neurospectroscopy?

被引：47

作者：

Martin, E ^{[1
]}

Capone, A

Schneider, J

Hennig, J

Thiel, T

机构：

[1] Univ Childrens Hosp Zurich, Dept Diagnost Imaging, Zurich, Switzerland

[2] Univ Childrens Hosp Zurich, Dept Neurol, Zurich, Switzerland

[3] Univ Hosp Freiburg, Sect Med Phys, Freiburg, Germany

来源：

ANNALS OF NEUROLOGY | 2001年 / 49卷 / 04期

关键词：

D O I：

10.1002/ana.102

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

N-acetylaspartate (NAA) contributes to the most prominent signal in proton magnetic resonance spectroscopy (H-1-MRS) of the adult human brain. We report the absence of NAA in the brain of a 3-year-old child with neurodevelopmental retardation and moderately delayed myelination. Since normal concentration of NAA in body fluids is hardly detectable, H-1-MRS is a noninvasive technique for identifying neurometabolic diseases with absent NAA. This report puts NAA as a neuronal marker to question.

引用

页码：518 / 521

页数：4

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