Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents

被引：122

作者：

Lim, Sun-Hye ^{[2
]}

Ha, Tae-Youl ^{[2
]}

Ahn, Jiyun ^{[2
]}

Kim, Suna ^{[1
]}

机构：

[1] Korea Natl Open Univ, Coll Nat Sci, Seoul 110791, South Korea

[2] Korea Food Res Inst, Food Funct Res Grp, Songnam 463746, South Korea

来源：

PHYTOMEDICINE | 2011年 / 18卷 / 05期

关键词：

Estrogenic activity; Bakuchiol; Psoralea corylifolia L; In vitro assays; BREAST-CANCER CELLS; REPLACEMENT THERAPY; GENISTEIN; APOPTOSIS; CHEMICALS; PROLIFERATION; MECHANISMS; FRACTIONS; INDUCTION; MCF-7;

D O I：

10.1016/j.phymed.2011.02.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Estrogenic activities of ethanol extract and its active components from Psoralea corylifolia L were studied using various in vitro assays. The main components from ethanol extract were analyzed to be bakuchiol, psoralen, isobavachalcone, isobavachromene, and bavachinin. In a fractionation procedure, hexane and chloroform fractions showed estrogenic activity in yeast transactivation assay and E-screen assay. In yeast transactivation assay, ethanol extract, hexane, and chloroform fractions showed significantly higher activities at a concentration of 1.0 ng/ml, and bakuchiol at the concentration of 10(-6) M was showed the highest activity, especially, which was higher than genistein at the same concentration. In E-screen assay, cell proliferation of bakuchiol (10(-6) M) showed similar estrogenic activity with genistein (10(-6) M). In ER binding assay, bakuchiol displayed the strongest ER-binding affinity (IC50 for ER alpha = 1.01 x 10(-6) M, IC50 for ER beta = 1.20 x 10(-6) M) and bakuchiol showed five times higher affinity for ER alpha than for ER beta. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：425 / 430

页数：6

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