Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women

被引:138
作者
Gao, Xiang
Qi, Lu
Qiao, Ning
Choi, Hyon K.
Curhan, Gary
Tucker, Katherine L.
Ascherio, Alberto
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[3] Tufts Univ, USDA, Human Nutr Res Ctr, Boston, MA 02111 USA
[4] Univ British Columbia, Vancouver Gen Hosp, Dept Med, Div Rheumatol, Vancouver, BC V5Z 1M9, Canada
[5] Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA
[6] Harvard Univ, Sch Med, Boston, MA 02115 USA
关键词
uric acid; beverages; added sugar; fructose; National Health and Nutrition Examination Survey;
D O I
10.1161/HYPERTENSIONAHA.107.091041
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Fructose-induced hyperuricemia might have a causal role in metabolic syndrome, hypertension, and other chronic disease. However, no study has investigated whether sugar added to foods or sugar-sweetened beverages, which are major sources of fructose, are associated with serum uric acid concentration in free-living populations. We examined the relationship between the intakes of added sugars and sugar-sweetened beverages and serum uric acid concentrations in the National Health and Nutrition Examination Survey 2001-2002, a nationally representative sample of men and women. We included 4073 subjects (1988 men and 2085 women) > 18 years of age in the current study. Dietary intake was assessed by a single 24- hour recall. We used multivariate linear regression to adjust for age, gender, intake of energy and alcohol, body mass index, use of diuretics, beta-blockers, and other covariates. Male subjects in the highest intake quartile of estimated intake of added sugars or sugar-sweetened drinks had higher plasma uric acid concentrations than those in the lowest intake quartiles (P < 0.001 for both) after adjusting for potential confounders, whereas we did not observe significant associations for females (P for trend > 0.2; P for interaction < 0.01). Further research is needed to confirm causality of these associations and the observed difference by gender.
引用
收藏
页码:306 / 312
页数:7
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